Cardiovascular disease is a pressing health problem with significant global health, societal, and financial burdens. Understanding the molecular basis of polygenic cardiac pathology is thus essential to devising novel approaches for management and treatment. Recent identification of uncharacterized regulatory functions for a class of nuclear envelope proteins called nucleoporins offers the opportunity to understand novel putative mechanisms of cardiac disease development and progression. Consistent reports of nucleoporin deregulation associated with ischemic and dilated cardiomyopathies, arrhythmias and valvular disorders suggests that nucleoporin impairment may be a significant but understudied variable in cardiopathologic disorders. This review discusses and converges existing literature regarding nuclear pore complex proteins and their association with cardiac pathologies, and proposes a role for nucleoporins as facilitators of cardiac disease.

中文翻译：

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核蛋白在心血管疾病中的作用。

心血管疾病是一个紧迫的健康问题，具有严重的全球健康，社会和经济负担。因此，了解多基因心脏病理学的分子基础对于设计新的管理和治疗方法至关重要。最近对一类称为核孔蛋白的核包膜蛋白未表征的调节功能的鉴定为了解心脏病发展和进展的新型推测机制提供了机会。与缺血性和扩张性心肌病，心律不齐和瓣膜疾病相关的核孔蛋白调节异常的一致报道表明，核孔蛋白损伤可能是心脏病理性疾病中的一个重要但被研究不足的变量。