Suga, N. Plasticity of the adult auditory system based on corticocortical and corticofugal modulations. NEUROSCI. BIOBEHAV. REV. XXX-XXX, 2020. Corticocortical and corticofugal modulations mediated by neurons in the lemniscal pathway are based on positive feedback associated with lateral inhibition and play an essential role not only in auditory signal processing, but also sound-specific plastic changes (e.g., frequency-tuning shifts) for the reorganization of the adult auditory system based on auditory experiences. The modulations evoke the facilitation of auditory responses of "tuning-matched" neurons and the tuning shifts of "tuning-unmatched" neurons in the auditory cortex and subcortical auditory nuclei. Here, "tuning-matched" means that the tuning properties of a recorded neuron are the same as those of an electrically stimulated cortical neuron or the frequency of tone burst stimuli. Tuning shifts, corticocortical and corticofugal modulations, evoked by focal cortical electric stimulation or tone burst stimulation are augmented by electric stimulation of the somatosensory cortex, acetylcholine application to the auditory cortex and associative learning such as auditory fear conditioning. Tuning shifts occur not only in the frequency domain, but also in the time, amplitude and spatial domains.

中文翻译：

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基于皮层和皮层调制的成人听觉系统的可塑性。

Suga，N.基于皮层和皮层调节的成人听觉系统的可塑性。神经科学 生化病毒 REV。2020年XXX-XXX年。在lemniscal通路中，神经元介导的皮层和皮层的调制基于与侧向抑制相关的正反馈，不仅在听觉信号处理中，而且在特定声音的塑性变化（例如，调整班次），以根据听觉经验重组成人听觉系统。调制唤起了“调节匹配”的神经元的听觉响应和听觉皮层和皮层下听核中“调节不匹配”的神经元的调节移位。在这里，“调整匹配” 表示记录的神经元的调节特性与电刺激的皮质神经元的调节特性或音调突发刺激的频率相同。局灶性皮层电刺激或声调爆发刺激引起的调音，皮层和皮质的调节，通过体感皮层的电刺激，向听性皮层的乙酰胆碱应用以及诸如听觉恐惧调节的联想学习得到增强。调谐偏移不仅发生在频域，而且还发生在时域，幅度和空间域。乙酰胆碱应用于听觉皮层和联想学习，如听觉恐惧条件。调谐偏移不仅发生在频域，而且还发生在时域，幅度和空间域。乙酰胆碱应用于听觉皮层和联想学习，如听觉恐惧条件。调谐偏移不仅发生在频域，而且还发生在时域，幅度和空间域。