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Effects of strontium amount on the mechanical strength and cell-biological performance of magnesium-strontium phosphate bioceramics for bone regeneration.
Biomaterials Advances ( IF 5.5 ) Pub Date : 2020-03-21 , DOI: 10.1016/j.msec.2020.110892
Fupo He 1 , Teliang Lu 2 , Xibo Fang 3 , Yanhui Li 3 , Fei Zuo 3 , Xin Deng 1 , Jiandong Ye 2
Affiliation  

Magnesium and strontium are able to enhance osteogenesis and suppress osteoclastic activities simultaneously, and they were nontoxic in wide concentration ranges; these make the magnesium-strontium phosphate bioceramics suitable for treating osteoporotic bone defects. The aim of this study was to investigate the effects of strontium amount on the mechanical strength and cell-biological performance of magnesium-strontium phosphate [MgxSr3-x(PO4)2; 3-x = 0, 0.1, 0.25, 0.5, 0.75, 1] bioceramics, which were sintered at 1100 °C. The results indicated that the magnesium-strontium phosphate bioceramics except Mg2.9Sr0.1(PO4)2 and Mg2.25Sr0.75(PO4)2 bioceramics had considerable compressive strength. The variation in magnesium and strontium contents did not regularly affect the in vitro osteogenic differentiation and osteoclastic activities. The Mg2.75Sr0.25(PO4)2 bioceramic had the most desirable overall performance, as reflected by considerably high compressive strength, enhanced in vitro osteogenesis and inhibited osteoclastic activities. Therefore, the Mg2.75Sr0.25(PO4)2 bioceramic is considered a promising biomaterial for osteoporotic bone regeneration.



中文翻译:

锶含量对磷酸镁锶生物陶瓷用于骨再生的机械强度和细胞生物学性能的影响。

镁和锶能够同时增强成骨作用和抑制破骨细胞活性,并且在很宽的浓度范围内都无毒。这些使磷酸镁锶生物陶瓷适合于治疗骨质疏松性骨缺损。本研究的目的是研究锶量对磷酸镁锶[Mg x Sr 3-x(PO 42的机械强度和细胞生物学性能的影响。[3-x = 0、0.1、0.25、0.5、0.75、1]生物陶瓷,其在1100℃下烧结。结果表明,除Mg 2.9 Sr 0.1(PO 42和Mg外,磷酸镁锶生物陶瓷2.25 Sr 0.75(PO 42生物陶瓷具有相当大的抗压强度。镁和锶含量的变化没有规律地影响体外成骨分化和破骨活性。Mg 2.75 Sr 0.25(PO 42生物陶瓷具有最理想的总体性能,这表现为相当高的抗压强度,增强的体外成骨作用和抑制破骨细胞活性。因此,Mg 2.75 Sr 0.25(PO 42生物陶瓷被认为是用于骨质疏松性骨再生的有前途的生物材料。

更新日期:2020-03-21
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