Magnesium and strontium are able to enhance osteogenesis and suppress osteoclastic activities simultaneously, and they were nontoxic in wide concentration ranges; these make the magnesium-strontium phosphate bioceramics suitable for treating osteoporotic bone defects. The aim of this study was to investigate the effects of strontium amount on the mechanical strength and cell-biological performance of magnesium-strontium phosphate [Mg_xSr_3-x(PO₄)₂; 3-x = 0, 0.1, 0.25, 0.5, 0.75, 1] bioceramics, which were sintered at 1100 °C. The results indicated that the magnesium-strontium phosphate bioceramics except Mg_2.9Sr_0.1(PO₄)₂ and Mg_2.25Sr_0.75(PO₄)₂ bioceramics had considerable compressive strength. The variation in magnesium and strontium contents did not regularly affect the in vitro osteogenic differentiation and osteoclastic activities. The Mg_2.75Sr_0.25(PO₄)₂ bioceramic had the most desirable overall performance, as reflected by considerably high compressive strength, enhanced in vitro osteogenesis and inhibited osteoclastic activities. Therefore, the Mg_2.75Sr_0.25(PO₄)₂ bioceramic is considered a promising biomaterial for osteoporotic bone regeneration.

镁和锶能够同时增强成骨作用和抑制破骨细胞活性，并且在很宽的浓度范围内都无毒。这些使磷酸镁锶生物陶瓷适合于治疗骨质疏松性骨缺损。本研究的目的是研究锶量对磷酸镁锶[Mg _x Sr _3-x（PO ₄）₂的机械强度和细胞生物学性能的影响。[3-x ＝ 0、0.1、0.25、0.5、0.75、1]生物陶瓷，其在1100℃下烧结。结果表明，除Mg _2.9 Sr _0.1（PO ₄）₂和Mg外，磷酸镁锶生物陶瓷_2.25 Sr _0.75（PO ₄）₂生物陶瓷具有相当大的抗压强度。镁和锶含量的变化没有规律地影响体外成骨分化和破骨活性。Mg _2.75 Sr _0.25（PO ₄）₂生物陶瓷具有最理想的总体性能，这表现为相当高的抗压强度，增强的体外成骨作用和抑制破骨细胞活性。因此，Mg _2.75 Sr _0.25（PO ₄）₂生物陶瓷被认为是用于骨质疏松性骨再生的有前途的生物材料。