Osteoarthritis, which is characterized by irreversible destruction of articular cartilage and severe inflammation of joint capsule, may be effectively treated via the synergistic therapy of lubrication restoration and local drug intervention. In this study, zwitterionic polymer-grafted mesoporous silica nanoparticles (MSNs@pSBMA) with the property of enhanced lubrication and sustained drug release were successfully synthesized via photopolymerization of 3-[dimethyl-[2-(2-methylprop-2-enoyloxy) ethyl] azaniumyl] propane-1-sulfonate polymer (pSBMA) on the surface of MSNs. The tribiological test showed that the lubrication performance of MSNs@pSBMA was remarkably improved, with a reduction of 80% in friction coefficient compared with MSNs. It was attributed to hydration lubrication mechanism by which a tenacious hydration layer was formed surrounding the N⁺(CH₂)₂(CH₃)₂ and SO₃⁻ headgroups in the pSBMA polyelectrolyte polymer. Additionally, the surface morphology analysis of the tribopairs demonstrated that MSNs@pSBMA were endowed with excellent anti-wear performance. Importantly, the drug release test illustrated that, compared with MSNs, MSNs@pSBMA achieved good sustained drug release behavior. In summary, the MSNs@pSBMA nanoparticles developed herein, as an injectable lubricant with enhanced lubrication and drug delivery, may represent a promising approach for the treatment of osteoarthritis.

以关节软骨不可逆转破坏和关节囊严重发炎为特征的骨关节炎可以通过润滑恢复和局部药物干预的协同治疗得到有效治疗。本研究通过3- [二甲基-[2-（2-（2-甲基丙-2-烯酰氧基）]乙基]的光聚合成功地合成了两性离子聚合物接枝的介孔二氧化硅纳米粒子（MSNs @ pSBMA），具有增强润滑性和持续释放药物的特性。 MSN表面上的[氮杂]氮杂]丙烷-1-磺酸盐聚合物（pSBMA）。摩擦学测试表明，MSNs @ pSBMA的润滑性能显着提高，与MSNs相比，摩擦系数降低了80％。⁺（CH ₂）₂（CH ₃）₂和SO ₃ ^-的pSBMA聚电解质聚合物在首基。此外，摩擦副的表面形态分析表明，MSNs @ pSBMA具有出色的抗磨性能。重要的是，药物释放试验表明，与MSNs相比，MSNs @ pSBMA具有良好的持续药物释放行为。总之，本文开发的MSNs @ pSBMA纳米颗粒作为具有增强的润滑性和药物递送性的可注射润滑剂，可以代表治疗骨关节炎的有前途的方法。