Graphene quantum dots (GQDs) were prepared by the pyrolysis of citric acid (CA), which were used for the loading of hydrophilic cytarabine (Cyt), an anti-cancer drug, and then wrapped with chitosan (CS) gels for the encapsulation of the loaded Cyt. The fluorescent stability of GQDs was significantly enhanced in the presence of CS, which might be attributed to the inhibited agglomeration of GQDs by the CS gels. In addition, the burst release of Cyt from the developed carrier was also effectively relieved by the CS coating. Since the incorporation of Cyt into GQDs was achieved by amidation reaction, the delivery of Cyt from the carrier was pH-sensitive due to the hydrolysis of the amido linkage between GQDs and Cyt in acidic medium.

石墨烯量子点（GQDs）是通过柠檬酸（CA）的热解制备的，用于负载抗癌药亲水阿糖胞苷（Cyt），然后用壳聚糖（CS）凝胶包裹以封装加载的Cyt。在CS存在下，GQD的荧光稳定性显着增强，这可能归因于CS凝胶抑制了GQD的团聚。另外，CS涂层还有效地减轻了Cyt从已开发载体的突释。由于通过酰胺化反应将Cyt掺入GQD中，由于在酸性介质中GQD和Cyt之间的酰胺键水解，因此从载体中递送Cyt对pH敏感。