Copper (Cu) based metal oxides have high electrocatalytic ability. In this work, we are synthesized stone-like cuprous oxide particles (Cu₂O SNPs) covered on acid functionalized graphene oxide (GOS) sheets using ultrasonic process (50 kHz and 100 W). Besides, the chemical structural and crystalline analyses of Cu₂O SNPs@GOS composites were characterized by transmission electron microscopy, X-ray crystallography and energy-dispersive X-ray spectroscopy. The Cu₂O SNPs@GOS nanomaterials were tested towards detection of 8-hydroxydeoxyguanosine (8-OHdG) in biological samples. As expected Cu₂O SNPs@GOS catalyst modified electrodes performed an outstanding catalytic ability on 8-hydroxydeoxyguanosine oxidation. 8-OHdG is oxidative stress biomarker. Further, it is noted that the detection performance of Cu₂O SNPs@GOS coated electrodes and it’s highly enhanced due to the synergistic effect of Cu₂O SNPs and GOS. Besides, the modified materials provide more electro-active faces and as well as rapid electron transport pathway and shorten diffusion. Moreover, oxidation of 8-OHdG sensor is exploring a long linear or working range of 0.02–1465 µM and high sensitivity (8.75 nM). The viability of the Cu₂O SNPs@GOS proposed electrochemical methods have tested, to find out 8-OHdG concentrations in biological fluids (blood serum and urine) with a satisfying recovery ranges.

铜（Cu）基金属氧化物具有高的电催化能力。在这项工作中，我们使用超声波处理（50 kHz和100 W）合成了覆盖在酸官能化氧化石墨烯（GOS）板上的石头状氧化亚铜颗粒（Cu ₂ O SNP）。此外，通过透射电子显微镜，X射线晶体学和能量色散X射线光谱学对Cu ₂ O SNPs @ GOS复合材料的化学结构和晶体分析进行了表征。测试了Cu ₂ O SNPs @ GOS纳米材料对生物样品中8-羟基脱氧鸟苷（8-OHdG）的检测。如预期的那样Cu ₂O SNPs @ GOS催化剂修饰的电极对8-羟基脱氧鸟苷的氧化表现出出色的催化能力。8-OHdG是氧化应激生物标志物。此外，应注意的是，检测性能的Cu ₂ ö的SNP @由于Cu的协同效应GOS涂覆电极，它的高度增强的₂ öSNP和GOS。此外，改性材料提供了更多的电活性面，以及快速的电子传输路径和缩短了扩散。此外，8-OHdG传感器的氧化正在探索0.02-1465 µM的长线性或工作范围以及高灵敏度（8.75 nM）。Cu ₂的生存力O SNPs @ GOS提出的电化学方法已经过测试，以找出具有令人满意的回收率的生物体液（血清和尿液）中的8-OHdG浓度。