During scientific investigations, the explanation of remarkably interesting phenomena must often await development of new methods or accrual of new observations that in retrospect can lead to lucid answers to the initial problem. A case in point is the control of genetic recombination during meiosis, which leads to crossovers between chromosomes critical for production of healthy offspring. Crossovers must be properly placed along meiotic chromosomes for their accurate segregation. Here, we review observations on two aspects of meiotic crossover control - crossover interference and repression of crossovers near centromeres, both observed more than 85 years ago. Only recently have relatively simple molecular mechanisms for these phenomena become clear through advances in both methods and understanding the molecular basis of meiotic recombination.

中文翻译：

---

老问题的新解决方案：减数分裂交叉控制的分子机制。


在科学研究过程中，对非常有趣的现象的解释通常必须等待新方法的发展或新观察的积累，回顾起来可以为最初的问题提供清晰的答案。一个典型的例子是减数分裂过程中基因重组的控制，这会导致染色体之间的交叉，这对于健康后代的产生至关重要。交叉必须沿着减数分裂染色体正确放置，以实现准确分离。在这里，我们回顾了减数分裂交叉控制的两个方面的观察结果——交叉干扰和着丝粒附近交叉的抑制，这两者都是在 85 年前观察到的。直到最近，通过这两种方法的进步以及对减数分裂重组分子基础的了解，这些现象的相对简单的分子机制才变得清晰。