Rapid advances in technologies in the field of genomics such as high throughput DNA sequencing, big data processing by machine learning algorithms and gene-editing techniques are expected to make precision medicine and gene-therapy a greater reality. However, this development will raise many important new issues, including ethical, moral, social and privacy issues. The field of exercise genomics has also advanced by incorporating these innovative technologies. There is therefore an urgent need for guiding references for sport and exercise genomics to allow the necessary advancements in this field of sport and exercise medicine, while protecting athletes from any invasion of privacy and misuse of their genomic information. Here, we update a previous consensus and develop a guiding reference for sport and exercise genomics based on a SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis. This SWOT analysis and the developed guiding reference highlight the need for scientists/clinicians to be well-versed in ethics and data protection policy to advance sport and exercise genomics without compromising the privacy of athletes and the efforts of international sports federations. Conducting research based on the present guiding reference will mitigate to a great extent the risks brought about by inappropriate use of genomic information and allow further development of sport and exercise genomics in accordance with best ethical standards and international data protection principles and policies. This guiding reference should regularly be updated on the basis of new information emerging from the area of sport and exercise medicine as well as from the developments and challenges in genomics of health and disease in general in order to best protect the athletes, patients and all other relevant stakeholders.

中文翻译：

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运动和运动基因组学：FIMS 2019 共识声明更新


高通量DNA测序、机器学习算法大数据处理和基因编辑技术等基因组学领域技术的快速进步有望使精准医疗和基因治疗成为现实。然而，这种发展将引发许多重要的新问题，包括伦理、道德、社会和隐私问题。通过整合这些创新技术，运动基因组学领域也取得了进步。因此，迫切需要为运动和运动基因组学提供指导参考，以便在运动和运动医学领域取得必要的进步，同时保护运动员的隐私免受侵犯和基因组信息的滥用。在这里，我们更新了之前的共识，并根据 SWOT（优势、劣势、机会和威胁）分析制定了运动和运动基因组学的指导参考。该 SWOT 分析和制定的指导参考强调了科学家/临床医生需要精通道德和数据保护政策，以在不损害运动员隐私和国际体育联合会努力的情况下推进运动和运动基因组学。基于本指导性参考开展研究将在很大程度上减轻基因组信息不当使用带来的风险，并根据最佳道德标准和国际数据保护原则和政策进一步发展运动和运动基因组学。 本指导参考应根据运动和运动医学领域以及健康和疾病基因组学的发展和挑战的新信息定期更新，以便最好地保护运动员、患者和所有其他人相关利益相关者。