Sodium-glucose cotransporters: Functional properties and pharmaceutical potential.,Journal of Diabetes Investigation

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Sodium-glucose cotransporters: Functional properties and pharmaceutical potential.
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2020-04-16 , DOI: 10.1111/jdi.13255
Ryuhei Sano ₁ , Yuichi Shinozaki ₁ , Takeshi Ohta ₂

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Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.

中文翻译：

钠-葡萄糖协同转运蛋白：功能特性和药物潜力。

葡萄糖是最丰富的单糖，是大多数活细胞的重要能量来源。跨细胞膜的葡萄糖转运由两种类型的转运蛋白介导：促进葡萄糖转运蛋白（基因名称：溶质载体 2A）和钠-葡萄糖协同转运蛋白（SGLT；基因名称：溶质载体 5A）。每个转运蛋白都有自己的底物特异性、分布和调节机制。近年来，SGLT1和SGLT2作为多种疾病的治疗靶点而备受关注。本综述讨论了葡萄糖转运蛋白和 SGLT 的基础和功能特性，并描述了 SGLT1 和 SGLT2 的药物潜力。

更新日期：2020-04-16

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