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Protective factors as biomarkers and targets for prevention and treatment of diabetic nephropathy: From current human evidence to future possibilities.
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2020-05-06 , DOI: 10.1111/jdi.13257 Natalia Nowak 1
Journal of Diabetes Investigation ( IF 3.1 ) Pub Date : 2020-05-06 , DOI: 10.1111/jdi.13257 Natalia Nowak 1
Affiliation
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Although hyperglycemia, high blood pressure and aging increase the risk of developing kidney complications, some diabetes patients exposed to these risk factors do not develop kidney disease, suggesting the presence of endogenous protective factors. There is a growing need to understand these factors determining protection of the kidney in order to improve the design of preventive strategies and to enhance the processes responsible for renoprotection. The aim of this review was to present the existing molecular and epidemiological data on factors showing protective effects in diabetic kidney disease, and to summarize the evidence regarding their potential in the area of future clinical diagnostics, therapeutics and early preventive strategies. These include transcriptomic and proteomic studies regarding the anti‐inflammatory, anti‐fibrotic and regenerative factors that were associated with slower progression of renal function loss. Another focus is the new evidence regarding the evaluation of alterations in the regulatory epigenome and its involvement in the risk of diabetic kidney disease. Further effort is required to validate and extend these findings, and to define their potential for clinical implementation in the future.
中文翻译：
保护因素作为糖尿病肾病预防和治疗的生物标志物和目标：从当前的人类证据到未来的可能性。
尽管高血糖、高血压和衰老会增加发生肾脏并发症的风险，但一些暴露于这些危险因素的糖尿病患者不会患上肾脏疾病，这表明存在内源性保护因素。人们越来越需要了解这些决定肾脏保护的因素，以便改进预防策略的设计并增强负责肾脏保护的过程。本综述的目的是介绍对糖尿病肾病具有保护作用的因素的现有分子和流行病学数据，并总结有关其在未来临床诊断、治疗和早期预防策略领域潜力的证据。其中包括关于与肾功能丧失进展缓慢相关的抗炎、抗纤维化和再生因子的转录组学和蛋白质组学研究。另一个焦点是关于评估表观基因组调节变化及其与糖尿病肾病风险的关系的新证据。需要进一步努力来验证和扩展这些发现，并确定其未来临床实施的潜力。
更新日期：2020-05-06
中文翻译：
保护因素作为糖尿病肾病预防和治疗的生物标志物和目标：从当前的人类证据到未来的可能性。
尽管高血糖、高血压和衰老会增加发生肾脏并发症的风险，但一些暴露于这些危险因素的糖尿病患者不会患上肾脏疾病，这表明存在内源性保护因素。人们越来越需要了解这些决定肾脏保护的因素，以便改进预防策略的设计并增强负责肾脏保护的过程。本综述的目的是介绍对糖尿病肾病具有保护作用的因素的现有分子和流行病学数据，并总结有关其在未来临床诊断、治疗和早期预防策略领域潜力的证据。其中包括关于与肾功能丧失进展缓慢相关的抗炎、抗纤维化和再生因子的转录组学和蛋白质组学研究。另一个焦点是关于评估表观基因组调节变化及其与糖尿病肾病风险的关系的新证据。需要进一步努力来验证和扩展这些发现，并确定其未来临床实施的潜力。
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