Designer self-assembling peptides form the entangled nanofiber networks in hydrogels by ionic-complementary self-assembly. This type of hydrogel has realistic biological and physiochemical properties to serve as biomimetic extracellular matrix (ECM) for biomedical applications. The advantages and benefits are distinct from natural hydrogels and other synthetic or semisynthetic hydrogels. Designer peptides provide diverse alternatives of main building blocks to form various functional nanostructures. The entangled nanofiber networks permit essential compositional complexity and heterogeneity of engineering cell microenvironments in comparison with other hydrogels, which may reconstruct the tumor microenvironments (TMEs) in 3D cell cultures and tissue-specific modeling in vitro. Either ovarian cancer progression or recurrence and relapse are involved in the multifaceted TMEs in addition to mesothelial cells, fibroblasts, endothelial cells, pericytes, immune cells, adipocytes, and the ECM. Based on the progress in common hydrogel products, this work focuses on the diverse designer self-assembling peptide hydrogels for instructive cell constructs in tissue-specific modeling and the precise oncology remodeling for ovarian cancer, which are issued by several research aspects in a 3D context. The advantages and significance of designer peptide hydrogels are discussed, and some common approaches and coming challenges are also addressed in current complex tumor diseases.

中文翻译：

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设计自组装肽水凝胶来设计 3D 细胞微环境，以促进卵巢癌细胞结构的形成和精确的肿瘤学重塑。

设计自组装肽通过离子互补自组装在水凝胶中形成缠结的纳米纤维网络。这种类型的水凝胶具有真实的生物和理化特性，可作为生物医学应用的仿生细胞外基质（ECM）。其优点和益处与天然水凝胶和其他合成或半合成水凝胶不同。设计肽提供了主要构建模块的多种替代方案，以形成各种功能性纳米结构。与其他水凝胶相比，缠结的纳米纤维网络允许工程细胞微环境的基本组成复杂性和异质性，这可以在3D细胞培养和体外组织特异性建模中重建肿瘤微环境（TME）。除了间皮细胞、成纤维细胞、内皮细胞、周细胞、免疫细胞、脂肪细胞和 ECM 之外，卵巢癌的进展或复发也涉及多方面的 TME。基于常见水凝胶产品的进展，本工作重点关注不同设计的自组装肽水凝胶，用于组织特异性建模中的指导性细胞构建和卵巢癌的精确肿瘤学重塑，这是由多个研究方面在3D背景下发布的。讨论了设计肽水凝胶的优点和意义，并讨论了当前复杂肿瘤疾病中的一些常见方法和即将面临的挑战。