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Effect of Ultrasonic Irradiation on the Probability of Primary Nucleation of L‐Arginine Hydrochloride
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2020-04-16 , DOI: 10.1002/ceat.201900636 Yuki Ike 1 , Izumi Hirasawa 1
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2020-04-16 , DOI: 10.1002/ceat.201900636 Yuki Ike 1 , Izumi Hirasawa 1
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Most of the amino acids that are utilized as medical raw materials and food additives show polymorphism. To improve the functionality of amino acid crystals, an effective method of polymorph control is required in the crystallization process. Here, primary nucleation of L‐arginine hydrochloride by ultrasonication was investigated. L‐Arginine hydrochloride exhibits polymorphism, and it crystallizes into three distinct crystal forms. A cooling crystallization experiment was performed, and nucleation of each polymorph upon ultrasonication was observed. In addition, the nucleation was analyzed using the nucleation probability theory. The results indicate that ultrasonic irradiation would significantly induce the nucleation of a particular polymorph.
中文翻译：
超声波辐照对盐酸左旋精氨酸初级成核概率的影响
用作医学原料和食品添加剂的大多数氨基酸都表现出多态性。为了改善氨基酸晶体的功能，在结晶过程中需要有效的多晶型物控制方法。在这里，研究了超声处理L-精氨酸盐酸盐的初级成核。L-精氨酸盐酸盐表现出多态性，并且结晶为三种不同的晶体形式。进行冷却结晶实验，并且观察到超声处理时每种多晶型物的成核。另外，使用成核概率理论分析了成核。结果表明，超声辐射将显着诱导特定多晶型物的成核。
更新日期：2020-04-16
中文翻译：
超声波辐照对盐酸左旋精氨酸初级成核概率的影响
用作医学原料和食品添加剂的大多数氨基酸都表现出多态性。为了改善氨基酸晶体的功能，在结晶过程中需要有效的多晶型物控制方法。在这里，研究了超声处理L-精氨酸盐酸盐的初级成核。L-精氨酸盐酸盐表现出多态性，并且结晶为三种不同的晶体形式。进行冷却结晶实验，并且观察到超声处理时每种多晶型物的成核。另外，使用成核概率理论分析了成核。结果表明，超声辐射将显着诱导特定多晶型物的成核。
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