Analysis of Morphological Changes in Monosodium Urate Monohydrate Crystals for Gout Treatment,Chemical Engineering & Technology

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Analysis of Morphological Changes in Monosodium Urate Monohydrate Crystals for Gout Treatment
Chemical Engineering & Technology ( IF 1.8 ) Pub Date : 2020-04-16 , DOI: 10.1002/ceat.201900634
Momoko Oda ₁ , Izumi Hirasawa ₁ , Fukashi Kohori ₁

Affiliation

Gout is arthritis induced by monosodium urate monohydrate (MSU) crystals. The treatment of gout is mainly a symptomatic treatment, by suppressing the blood uric acid concentration with drugs. Here, the changes in crystal morphology in the process of MSU crystallization were investigated. Experiments were conducted to clarify the mechanisms of nucleation and growth of the MSU crystals, revealing that MSU first precipitated as granular crystals. Thereafter, nucleation and growth of needle‐like crystals were observed concomitant with the disappearance of the granular crystals. These results suggest that it is necessary to suppress the nucleation of granular crystals and the change in morphology from granular to needle‐like of the MSU crystals that cause gout.

中文翻译：

用于治疗痛风的一水合一水合尿酸钠结晶的形态变化分析

痛风是由尿酸钠一水合物（MSU）晶体诱发的关节炎。痛风的治疗主要是对症治疗，方法是用药物抑制血尿酸浓度。在此，研究了MSU结晶过程中晶体形态的变化。进行实验以阐明MSU晶体的成核和生长机理，发现MSU首先以粒状晶体形式沉淀。此后，观察到针状晶体的成核和生长，伴随着粒状晶体的消失。这些结果表明，有必要抑制引起痛风的MSU晶体的粒状形核和从粒状到针状的形态变化。

更新日期：2020-04-16

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