Effect of Polymer Concentration on Autoclaved Cryogel Properties,Macromolecular Materials and Engineering

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Effect of Polymer Concentration on Autoclaved Cryogel Properties
Macromolecular Materials and Engineering ( IF 4.2 ) Pub Date : 2020-03-20 , DOI: 10.1002/mame.201900824
Adnan Memic ₁ , Mahboobeh Rezaeeyazdi ₁ , Pierre Villard _{1,

2} , Zachary J. Rogers ₂ , Tuerdimaimaiti Abudula ₁ , Thibault Colombani ₂ , Sidi A. Bencherif _{2,

3,

4,

5}

Affiliation

Biomaterial sterilization is a prerequisite prior to patient's use, especially for scaffold implantation or injection. Various sterilization processes are mandated by the Food and Drug Administration including high‐pressure steam sterilization. Although high‐pressure steam or autoclave sterilization eliminates pathogens, it often leads to irreversible damages on soft materials such as hydrogels. In the current study, the impact of autoclave sterilization on cryogels made from several naturally‐derived polymeric precursors (alginate, hyaluronic acid, and gelatin) is analyzed. Specifically, the impact of polymer concentration on the structural and physical properties of autoclaved cryogels such as mechanics, swelling ratio, pore interconnectivity, and shape‐memory features is studied. The results demonstrate that at a given optimal polymer concentration, unique for each biopolymer investigated, autoclave sterilization does not substantially alter the microarchitectural or physical characteristics of cryogels, including their syringe injectability signature. In summary, when formulated under optimized polymer concentrations, autoclavable cryogels hold great potential for several biomedical applications, as they can be easily translated into clinical practice to benefit public health.

中文翻译：

聚合物浓度对高压灭菌冰冻凝胶性能的影响

生物材料灭菌是患者使用之前的先决条件，尤其是对于支架植入或注射。美国食品药品管理局（FDA）要求采取各种灭菌方法，包括高压蒸汽灭菌。尽管高压蒸汽或高压灭菌器可以消除病原体，但通常会对水凝胶等软质材料造成不可逆转的损害。在当前的研究中，分析了高压灭菌对由几种天然聚合物前体（藻酸盐，透明质酸和明胶）制成的冰冻凝胶的影响。具体而言，研究了聚合物浓度对高压灭菌冰晶的结构和物理性能的影响，例如力学，溶胀率，孔互连性和形状记忆特征。结果表明，在给定的最佳聚合物浓度下（对于所研究的每种生物聚合物而言都是唯一的），高压灭菌器基本上不会改变冷冻凝胶的微结构或物理特性，包括其注射器的可注射性。总而言之，当在最佳聚合物浓度下配制时，可高压灭菌的冰凝胶在多种生物医学应用中具有巨大的潜力，因为它们可以轻松地转化为临床实践以造福公众健康。

更新日期：2020-03-20

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