In this study, we prepared carbon dots (CDs) from wheat bran via hydrothermal treatment at 180°C for 3 h. The prepared CDs showed blue‐green fluorescence under UV light. The fluorescence emission study of the CDs revealed that they showed maximum fluorescence emission at 500 nm. The prepared CDs showed a high quantum yield of 33.23%. Solvent‐dependent fluorescence emission analysis of the CDs was performed to study the variation in fluorescence emission characteristics with solvent polarity. The prepared CDs were conjugated with amoxicillin (AMX) to explore its potential for use as a drug delivery agent for AMX. The drug release profile of the CD–AMX conjugates was analyzed at different pH (5.0, 6.8 and 7.2) to study drug release kinetics. CD–AMX conjugates showed notable bacterial inhibition against Gram‐positive (S. aureus) and Gram‐negative (E. coli) strains with minimal cytotoxic effects, indicating its potential as a promising antibacterial drug delivery system.

中文翻译：

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来自麦麸的高荧光碳点，可作为抑制细菌的新型药物递送系统。

在这项研究中，我们通过在180°C进行3 h的水热处理，从麦麸中制备了碳点（CD）。制备的CD在紫外线下显示出蓝绿色荧光。CD的荧光发射研究表明，它们在500 nm处显示最大荧光发射。制备的CD显示出33.23％的高量子产率。对CD进行了溶剂依赖性的荧光发射分析，以研究荧光发射特性随溶剂极性的变化。将制备的CD与阿莫西林（AMX）偶联，以探索其用作AMX药物递送剂的潜力。在不同的pH（5.0、6.8和7.2）下分析了CD-AMX偶联物的药物释放曲线，以研究药物释放动力学。CD–AMX偶联物对革兰氏阳性菌（S. 金黄色葡萄球菌和革兰氏阴性（E. coli）菌株具有最小的细胞毒性作用，表明其作为有前途的抗菌药物递送系统的潜力。