New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406.,ChemBioChem

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New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-03-20 , DOI: 10.1002/cbic.202000062
Julia Chen _{1,

2} , Andri Frediansyah _{1,

2,

3} , Daniel Männle _{1,

2,

4} , Jan Straetener _{2,

5} , Heike Brötz-Oesterhelt _{2,

5} , Nadine Ziemert _{2,

4} , Leonard Kaysser _{1,

2} , Harald Gross _{1,

2}

Affiliation

Nature's combinatorial biosynthesis produces new bioactive nocobactin derivatives. Genome mining led to the discovery and characterization of terpenibactins A−C, three new nocobactins from the bacterium Nocardia terpenica IFM 0406 that exhibit unprecedented combinations of asteroidic acid, lipid and modified lysine residues. They demonstrate low cytotoxicity but potent inhibitory activity towards the muscarinic M3 receptor.

中文翻译：

通过诺卡氏菌 IFM 0406 的基因组挖掘揭示了具有抗毒蕈碱活性的新型诺卡菌素衍生物 Terpenibactins AC。

大自然的组合生物合成产生新的生物活性诺考菌素衍生物。基因组挖掘导致了 terpenibactins A−C 的发现和表征，这是来自细菌Nocardia terpenica IFM 0406 的三种新诺卡菌素，它们表现出前所未有的星形酸、脂质和修饰赖氨酸残基的组合。它们表现出低细胞毒性，但对毒蕈碱 M3 受体具有有效的抑制活性。

更新日期：2020-03-20

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