Rh-Catalyzed C-H activation/intramolecular condensation for the construction of benzo[f]pyrazolo[1,5-a][1,3]diazepines.,Organic & Biomolecular Chemistry

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Rh-Catalyzed C-H activation/intramolecular condensation for the construction of benzo[f]pyrazolo[1,5-a][1,3]diazepines.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-04-15 , DOI: 10.1039/d0ob00382d
Yi Ning ₁ , Xinwei He ₁ , Youpeng Zuo ₁ , Jian Wang ₁ , Qiang Tang ₁ , Mengqing Xie ₁ , Ruxue Li ₁ , Yongjia Shang ₁

Affiliation

A novel and mild Rh(iii)-catalyzed C-H activation/intramolecular condensation of 1-aryl-1H-pyrazol-5-amines with cyclic 2-diazo-1,3-diketones was developed, giving access to various important benzo[f]pyrazolo[1,5-a][1,3]diazepine scaffolds through sequential C-C/C-N bond formation in a one-pot procedure under additive- and oxidant-free conditions. Furthermore, 3-([1,1'-biphenyl]-2-ylamino)-2-ethoxycyclohex-2-enones can be obtained in good yields by constructing C-O and C-N bonds through 1,1'-insertion, dehydration, and isomerization processes.

中文翻译：

Rh催化的CH活化/分子内缩合反应用于构建苯并[f]吡唑并[1,5-a] [1,3]二氮杂s。

开发了一种新型且温和的Rh（iii）催化1-芳基-1H-吡唑-5-胺与环状2-重氮-1,3-二酮的CH活化/分子内缩合，从而获得了各种重要的苯并[f]。吡唑并[1,5-a] [1,3]二氮杂sc骨架在无添加剂和无氧化剂条件下，通过一锅法通过顺序CC / CN键形成。此外，通过1,1'插入，脱水和异构化构建CO和CN键，可以高收率获得3-（[（1,1'-联苯] -2-基氨基）-2-乙氧基环己基-2-烯酮流程。

更新日期：2020-04-24

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