Direct synthesis of ortho-methylthio allyl and vinyl ethers via three component reaction of aryne, activated alkene and DMSO.,Organic & Biomolecular Chemistry

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Direct synthesis of ortho-methylthio allyl and vinyl ethers via three component reaction of aryne, activated alkene and DMSO.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-04-08 , DOI: 10.1039/d0ob00275e
Hemanta Hazarika ₁ , Pranjal Gogoi ₁

Affiliation

A synthetic strategy has been developed for the direct synthesis of ortho-methylthio allyl and vinyl ethers via three-component reaction of in situ generated aryne, activated alkene and DMSO. This reaction proceeds via several bond cleavage and bond formation processes in a single operation. Mechanistic studies reveal that DMSO served as both a methylthiolating agent and an oxygen source. This synthetic method provides a wide range of ortho-methylthio-substituted arenes in good yields.

中文翻译：

通过芳烃，活化烯烃和DMSO的三组分反应直接合成邻甲硫基烯丙基和乙烯基醚。

已经开发了通过原位生成的芳烃，活化的烯烃和DMSO的三组分反应直接合成邻甲硫基烯丙基和乙烯基醚的合成策略。该反应在一次操作中通过数个键裂解和键形成过程进行。机理研究表明，DMSO既可以用作甲基硫醇化剂，又可以用作氧气源。该合成方法以高收率提供了多种邻甲硫基取代的芳烃。

更新日期：2020-04-24

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