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Coinfections of Novel Polyomavirus, Anelloviruses and a Recombinant Strain of Myxoma Virus-MYXV-Tol Identified in Iberian Hares.
Viruses ( IF 3.8 ) Pub Date : 2020-03-20 , DOI: 10.3390/v12030340
Ana Águeda-Pinto 1, 2, 3 , Simona Kraberger 3, 4 , Michael C Lund 4 , Christian Gortázar 5 , Grant McFadden 3 , Arvind Varsani 4, 6 , Pedro J Esteves 1, 2, 7
Affiliation  

Viruses are ubiquitous in nature; however, very few have been identified in the Leporid species. In the fall of 2018, an outbreak of myxomatosis in Iberian hares (Lepus granatensis) was reported in Spain and a novel recombinant myxoma virus strain (MYXV-Tol) was identified. To investigate variability within the recombinant region of the MYXV-Tol and identify any potential viral coinfections, samples (ear, eyelid or vaginal) of Iberian hares were collected from Spain and analyzed. The presence of the recombinant region of the MYXV-Tol was confirmed in six out of eleven samples analyzed. Additionally, a polyomavirus (family Polyomaviridae), representing a putative new species, and anelloviruses (family Anelloviridae) belonging to two putative species were identified, some as coinfection with the recombinant MYXV-Tol. The two polyomavirus genomes were identified in two hares and share >99% genome-wide identity. Based on the analysis of their large T-antigen, the new polyomavirus clusters in a distant clade from other mammals sharing <64% amino acid identity. A total of 14 anelloviruses were identified, which share 63-99% genome-wide identity. Overall, our results show a coinfection of different DNA viruses in the studied samples and raise awareness regarding the extensive unsampled diversity of viruses in hares.

中文翻译:


在伊比利亚野兔中鉴定出新型多瘤病毒、指环病毒和粘液瘤病毒-MYXV-Tol 重组株的混合感染。



病毒在自然界中无处不在;然而,在兔科动物中发现的数量很少。 2018 年秋季,西班牙报告了伊比利亚野兔(Lepus granatensis)爆发粘液瘤病,并鉴定出一种新的重组粘液瘤病毒株(MYXV-Tol)。为了研究 MYXV-Tol 重组区域内的变异性并识别任何潜在的病毒双重感染,从西班牙收集了伊比利亚野兔的样本(耳朵、眼睑或阴道)并进行了分析。在所分析的 11 个样品中,有 6 个样品证实了 MYXV-Tol 重组区域的存在。此外,还鉴定了代表推定新种的多瘤病毒(多瘤病毒科)和属于两个推定种的指环病毒(指环病毒科),其中一些与重组 MYXV-Tol 共感染。这两种多瘤病毒基因组在两只野兔中得到鉴定,并且具有 >99% 的全基因组同一性。根据对大 T 抗原的分析,新的多瘤病毒与其他哺乳动物的进化支相距较远,氨基酸同一性低于 64%。总共鉴定出 14 种指环病毒,它们具有 63-99% 的全基因组同一性。总体而言,我们的结果显示所研究的样本中存在不同 DNA 病毒的共感染,并提高了人们对野兔中广泛的未采样病毒多样性的认识。
更新日期:2020-03-21
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