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A new ratiometric electrochemical sensor using electroactive GO/MB/Ag nanocomposites for H 2 S detection in biological samples
Journal of Nanoparticle Research ( IF 2.1 ) Pub Date : 2020-03-20 , DOI: 10.1007/s11051-020-4774-0
Hongyuan Shang , Hui Xu , Cheng Wang , Chunyan Chen , Caiqin Wang , Liujun Jin , Yukou Du

Abstract

In this study, we report a new ratiometric electrochemical sensor to accurately and selectively detect hydrogen sulfide (H2S) in biological samples. In this system, it contains electroactive Ag dendritic nanocomposites (NCs) as a special recognition element of H2S and methylene blue (MB) as an inner reference molecular for a built-in correction to improve the accuracy. The Ag NCs are prepared and synthesized by a electrodeposition method, and the branches consist of rounded and smooth segments with a diameter of about 300 nm. In the presence of H2S, combining with the good adsorption ability of GO and more active sites of dendritic Ag nanostructure, the Ag NCs of GO/MB/Ag can be oxidized to Ag2S in the oxygen environment, resulting in the decrease of electrochemical oxidation peaks of Ag (0.42 V) and constant of current responses of MB. On the basis of the ratio of IAg/IMB at two distinct potentials, the developed ratiometric electrochemical sensor displays a wide linear range from 30 to 500 μM with high accuracy, selectivity, and stability. This strategy provides a reliable and feasible method for the detections of H2S in real samples, including biological samples related to physiological and pathological events of hydrogen sulfide production.

Graphical abstract



中文翻译:

一种使用电活性GO / MB / Ag纳米复合材料的新型比例电化学传感器,用于生物样品中H 2 S的检测

摘要

在这项研究中,我们报告了一种新的比率式电化学传感器,可以准确,选择性地检测生物样品中的硫化氢(H 2 S)。在该系统中,它包含电活性Ag树突状纳米复合材料(NCs)作为H 2 S的特殊识别元素,并包含亚甲基蓝(MB)作为内部参考分子,用于内置校正以提高准确性。Ag NCs是通过电沉积方法制备和合成的,其分支由直径约300 nm的圆滑段组成。在H 2 S存在下,结合GO的良好吸附能力和树枝状Ag纳米结构的更多活性位,GO / MB / Ag的Ag NCs可以被氧化为Ag 2S在氧气环境中,导致Ag(0.42 V)的电化学氧化峰减少,MB的电流响应恒定。基于在两个不同电势下I Ag / I MB的比率,开发的比率式电化学传感器显示了30至500μM的宽线性范围,具有高精度,高选择性和稳定性。该策略为实际样品中的H 2 S检测提供了一种可靠可行的方法,其中包括与硫化氢生产的生理和病理事件有关的生物样品。

更新日期:2020-03-21
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