OBJECTIVES: The prevalence of psychiatric disease in patients with eosinophilic esophagitis (EoE) is not fully characterized. We aimed to determine the prevalence of psychiatric disease and centrally acting medication use in a cohort of children and adults with EoE and evaluated whether psychiatric disease affects the EoE clinical presentation. METHODS: We conducted a retrospective study of newly diagnosed cases with EoE at the University of North Carolina from 2002 to 2018. Psychiatric comorbidities and relevant treatments were extracted from the medical records. The demographic and clinical features of patients with EoE with and without psychiatric diagnoses, and those with and without psychiatric medication use, were compared. RESULTS: Of 883 patients (mean age 26.6 years, 68% men, 79% white), 241 (28%) had a psychiatric comorbidity. The most common diagnosis was anxiety (23%) followed by depression (17%); 28% of patients were treated pharmacologically. There were 45 patients (5%) treated pharmacologically without a psychiatric diagnosis for chronic pain syndromes, insomnia, and/or epilepsy. Cases with EoE with a psychiatric diagnosis were more likely to be women, white, and 18 years or older and to have a longer symptom duration before diagnosis. DICUSSION: Psychiatric comorbidities were common in EoE, seen in a third of adults and more than 1 in 7 children, and with similar proportions receiving a prescription medication. These illnesses affected the EoE presentation because psychiatric comorbidities were more likely in older, female, and white patients with a longer duration of symptoms preceding diagnosis. Correspondence: Evan S. Dellon, MD, MPH. E-mail: edellon@med.unc.edu. Received September 13, 2019 Accepted February 25, 2020 © The American College of Gastroenterology 2020. All Rights Reserved.

中文翻译：

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嗜酸性食管炎患者的精神科合并症和精神科药物使用非常普遍，并且与临床表现有关。

目的：嗜酸性食管炎 (EoE) 患者的精神疾病患病率尚未完全确定。我们旨在确定 EoE 儿童和成人队列中精神疾病的患病率和中枢作用药物的使用情况，并评估精神疾病是否影响 EoE 的临床表现。方法：我们对 2002 年至 2018 年在北卡罗来纳大学新诊断的 EoE 病例进行了回顾性研究。从病历中提取了精神病合并症和相关治疗。比较了有和没有精神科诊断的 EoE 患者以及有和没有使用精神科药物的患者的人口统计学和临床​​特征。结果：在 883 名患者（平均年龄 26.6 岁，68% 男性，79% 白人）中，241 名（28%）患有精神疾病。最常见的诊断是焦虑（23%），其次是抑郁（17%）；28%的患者接受了药物治疗。有 45 名患者 (5%) 接受了药物治疗，但没有进行慢性疼痛综合征、失眠和/或癫痫的精神病学诊断。具有精神病学诊断的 EoE 病例更有可能是女性、白人、18 岁或以上，并且在诊断前症状持续时间较长。讨论：精神病合并症在 EoE 中很常见，见于三分之一的成年人和超过七分之一的儿童，并且接受处方药的比例相似。这些疾病影响了 EoE 的表现，因为在诊断前症状持续时间较长的老年、女性和白人患者中更有可能出现精神疾病。通讯作者：Evan S. Dellon，医学博士，公共卫生硕士。电子邮件：edellon@med.unc。教育。2019 年 9 月 13 日收到 2020 年 2 月 25 日接受 © The American College of Gastroenterology 2020。保留所有权利。