Multicomponent reactions (MCRs) constitute a powerful synthetic tool to generate a large number of small molecules with high atom economy, which thus can efficiently expand the chemical space with molecular diversity and complexity. Aryne-based MCRs offer versatile possibilities to construct functionalized arenes and benzo-fused heterocycles. Because of their electrophilic nature, arynes couple with a broad range of nucleophiles. Thus, a variety of aryne-based MCRs have been developed, the representative of which are summarized in this account. 1 Introduction 2 Aryne-Based Multicomponent Reactions 2.1 Trapping with Isocyanides 2.2 Trapping with Imines 2.3 Trapping with Amines 2.4 Insertion into π-Bonds 2.5 Trapping with Ethers and Thioethers 2.6 Trapping with Carbanions 2.7 Transition-Metal-Catalyzed Approaches 3 Strategies Based on Hexadehydro Diels–Alder Reaction 3.1 Dihalogenation 3.2 Halohydroxylation and Haloacylation 3.3 Amides and Imides 3.4 Quinazolines 3.5 Benzocyclobutene-1,2-diimines and 3H-Indole-3-imines 3.6 Other MCRs of Arynes and Isocyanides 4 Conclusion

中文翻译：

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基于 Aryne 的多组分偶联反应

多组分反应（MCRs）构成了一种强大的合成工具，可以产生大量具有高原子经济性的小分子，从而可以有效地扩展具有分子多样性和复杂性的化学空间。基于芳烃的 MCR 为构建功能化芳烃和苯并稠合杂环提供了多种可能性。由于其亲电性质，芳炔可与多种亲核试剂结合。因此，已经开发了多种基于芳炔的 MCR，本报告总结了其中的代表。1 介绍 2 基于芳炔的多组分反应 2.1 用异氰化物捕获 2.2 用亚胺捕获 2.3 用胺捕获 2.4 插入 π 键 2.5 用醚和硫醚捕获 2.6 用碳负离子捕获 2.