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Ligand-Free and Solvent-Free Synthesis of 1,3-Disubstituted Naphthalenes through Stille Coupling
Synlett ( IF 1.7 ) Pub Date : 2020-03-20 , DOI: 10.1055/s-0039-1690850
Taoufik Rohand 1 , Sanae Sbi 1 , Victor Mkpenie 2 , Kiyoshi Tanemura 3
Affiliation  

A variety of 1,3-disubstituted naphthalenes have been prepared by palladium-catalyzed annulation of (o-ethynylphenyl)acetyl chloride with design of a new synthetic strategy by Stille coupling using functionalized organostannanes. The method affords excellent yields of the substituted naphthalenes and accommodates a wide variety of functional groups under mild conditions. Mechanistic studies show intramolecular cyclization as a major step following C–C bond coupling.

中文翻译:

通过Stille偶联无配体无溶剂合成1,3-二取代萘

多种 1,3-二取代萘已通过钯催化的(邻乙炔基苯基)乙酰氯环化制备,并设计了一种使用功能化有机锡烷的 Stille 偶联新合成策略。该方法提供了优异的取代萘收率,并在温和的条件下容纳了多种官能团。机理研究表明,分子内环化是 C-C 键偶联后的一个主要步骤。
更新日期:2020-03-20
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