Inherited retinal diseases (IRDs) are clinically and genetically heterogenous diseases affecting the neural retina and retinal pigment epithelium resulting in irreversible blindness. Owing to advantages like ease of access for treatment, one eye being a perfect natural control for the other, and immune privileged environment, research exploring treatment for these retinal diseases has advanced remarkably. We describe the generation of induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMC) of three patients with IRDs. These well-characterized iPSC lines provide an ideal platform to investigate normal and pathological retinogenesis for drug screening and personalized cell therapy.

遗传性视网膜疾病 (IRD) 是影响神经视网膜和视网膜色素上皮细胞的临床和遗传异质性疾病，可导致不可逆转的失明。由于易于获得治疗、一只眼睛是另一只眼睛的完美自然控制以及免疫特权环境等优势，探索这些视网膜疾病治疗的研究取得了显着进展。我们描述了从三名 IRD 患者的外周血单核细胞 (PBMC) 中诱导多能干细胞 (iPSC) 系的生成。这些特征良好的 iPSC 细胞系为研究正常和病理性视网膜发生以进行药物筛选和个性化细胞治疗提供了一个理想的平台。