Experimental information from microscopy, structural biology, and bioinformatics may be integrated to build structural models of entire cells with molecular detail. This integrative modeling is challenging in several ways: the intrinsic complexity of biology results in models with many closely packed and heterogeneous components; the wealth of available experimental data is scattered among multiple resources and must be gathered, reconciled, and curated; and computational infrastructure is only now gaining the capability of modeling and visualizing systems of this complexity. We present recent efforts to address these challenges, both with artistic approaches to depicting the cellular mesoscale, and development and application of methods to build quantitative models.

中文翻译：

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细胞介尺度的艺术与科学。


来自显微镜、结构生物学和生物信息学的实验信息可以整合起来，建立具有分子细节的整个细胞的结构模型。这种综合建模在几个方面具有挑战性：生物学的内在复杂性导致模型具有许多紧密堆积和异质的成分；大量可用的实验数据分散在多种资源中，必须进行收集、协调和整理；计算基础设施现在才获得对这种复杂系统进行建模和可视化的能力。我们介绍了最近为解决这些挑战所做的努力，包括用艺术方法来描绘细胞介观尺度，以及开发和应用建立定量模型的方法。