The Golgi apparatus serves as a receiving station where proteins from the endoplasmic reticulum (ER) are further processed before being sent to other cellular compartments. In addition to its well-appreciated roles in vesicular trafficking and protein/lipid secretion, recent studies have demonstrated that the Golgi acts as a signaling platform to facilitate multiple innate immune pathways. Moreover, the membranous networks that connect the Golgi with the ER, mitochondria, endosomes, and autophagosomes provide convenient access to innate immune signal transduction and subsequent effector responses. Here, we review the emerging knowledge about the roles of the Golgi in the initiation and activation of innate immune signaling. Moreover, microbial hijacking strategies that inhibit Golgi-associated innate immune responses will also be discussed.

中文翻译：

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高尔基仪：一种先天免疫的新兴平台。

高尔基体作为接收站，来自内质网（ER）的蛋白质在被发送到其他细胞室之前被进一步处理。除了其在水泡运输和蛋白质/脂质分泌中广为人知的作用外，最近的研究表明，高尔基体起促进多种先天免疫途径的信号传导平台的作用。此外，将高尔基体与内质网，线粒体，内体和自噬体连接起来的膜状网络为先天免疫信号转导和随后的效应子反应提供了便利。在这里，我们回顾有关高尔基在先天免疫信号的启动和激活中的作用的新兴知识。此外，还将讨论抑制高尔基体相关先天免疫反应的微生物劫持策略。