BACKGROUND Placental endocrine insufficiency may increase the risk of depression and anxiety during pregnancy and/or after birth. This study investigated the association between serum human placental lactogen (hPL) and measures of perinatal mental health, accounting for selective serotonin-reuptake inhibitor (SSRI) usage. METHOD Caucasian women with singleton, term pregnancies recruited at their pre-surgical appointment prior to an elective caesarean section (ELCS) were studied. Serum hPL levels were measured by ELISA in maternal blood collected at the pre-surgical appointment. Depression and anxiety scores were derived from Edinburgh Postnatal Depression Scale (EPDS) and the trait subscale of the State-Trait Anxiety Inventory (STAI) questionnaires completed at recruitment and three postnatal time points. Data was analysed by unadjusted and adjusted multiple linear regression. RESULTS In adjusted linear regressions, term maternal serum hPL levels were negatively associated with postnatal EPDS and STAI score ten weeks postnatal for mothers who had girls (B= -.367, p = .022, 95% CI -.679, -.056; and B= -.776, p = .030, 95% CI -1.475, -.077 respectively). Excluding women prescribed SSRIs strengthened the relationship at 10 weeks and uncovered an earlier association between hPL and mood scores within one week of delivery (EPDS B= -.357, p = .041, 95 % CI -.698, -.015; and STAI B= -.737, p = .027, 95 % CI -1.387, -.086). In mothers who had boys, there were no associations between hPL and mood scores at any time point. CONCLUSION Low hPL at term associated with postnatal depression and anxiety symptoms exclusively in mothers of girls. Insufficiency in hPL may contribute to maternal mood symptoms.

中文翻译：

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足月低血清胎盘催乳素与分娩女婴的妇女的产后抑郁和焦虑症状有关

背景胎盘内分泌功能不全可能会增加怀孕期间和/或出生后抑郁和焦虑的风险。本研究调查了血清人类胎盘催乳素 (hPL) 与围产期心理健康指标之间的关联，解释了选择性血清素再摄取抑制剂 (SSRI) 的使用。方法 研究了在择期剖腹产 (ELCS) 之前在术前预约时招募的单胎、足月妊娠的白人女性。血清 hPL 水平通过 ELISA 在术前预约时收集的母体血液中测量。抑郁和焦虑评分来自爱丁堡产后抑郁量表 (EPDS) 和在招募和三个产后时间点完成的状态-特质焦虑量表 (STAI) 问卷的特质分量表。通过未调整和调整的多元线性回归分析数据。结果 在调整后的线性回归中，足月母亲血清 hPL 水平与产后 EPDS 和 STAI 评分呈负相关，对于有女孩的母亲，出生后 10 周（B= -.367, p = .022, 95% CI -.679, -.056 ; 和 B= -.776, p = .030, 95% CI 分别为 -1.475, -.077)。排除服用 SSRI 的女性在 10 周时加强了这种关系，并发现了分娩后一周内 hPL 与情绪评分之间的早期关联（EPDS B= -.357, p = .041, 95 % CI -.698, -.015；和STAI B= -.737, p = .027, 95 % CI -1.387, -.086)。在生男孩的母亲中，任何时间点的 hPL 和情绪评分之间都没有关联。结论 足月低 hPL 与产后抑郁和焦虑症状仅在女孩的母亲中有关。