Abstract Hydroxyapatite (HAP) is the main inorganic component of human skeletal tissue such as bone, teeth et al. Because of its excellent biocompatibility, biodegradability and mechanical properties, it is widely applied in the field of medicine, particularly in bone repairing and drug release. However, it is difficult to prepare HAP particles with good dispersity in aqueous solution and high surface area. To solve the issue, porous CaCO3 were taken as a template to prepare hydroxyapatite with good dispersity and high surface area assisted by a dipeptide hydrogel system. Experimental data show that the sequence of dipeptide has a great effect on the dispersity of hydroxyapatite particles, and the obtained hydroxyapatite has a same particle size with the template of CaCO3, and can be dispersed in an aqueous solution very well. Meanwhile porous hydroxyapatite particles have a large surface area benefiting the loading of model drugs, and illustrate enhanced cell internalization efficiency and low cytotoxicity, which can be used as a sustained-release drug carrier.

中文翻译：

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在二肽水凝胶中以碳酸钙为模板制备具有高表面积和分散性的羟基磷灰石

摘要 羟基磷灰石（HAP）是人体骨骼、牙齿等骨骼组织的主要无机成分。由于其优异的生物相容性、生物降解性和力学性能，被广泛应用于医学领域，特别是在骨修复和药物释放方面。然而，难于制备在水溶液中具有良好分散性和高表面积的HAP颗粒。为了解决这个问题，以多孔碳酸钙为模板，在二肽水凝胶系统的辅助下制备了具有良好分散性和高表面积的羟基磷灰石。实验数据表明，二肽的排列顺序对羟基磷灰石颗粒的分散性影响很大，得到的羟基磷灰石与CaCO3模板具有相同的粒径，可以很好地分散在水溶液中。