Cupressus macrocarpa is a windbreak tree and is reported to have various cytotoxic effects. A natural product study on the leaves of C. macrocarpa has yielded ten secondary metabolites, including three new diterpenoids (1–3), four known diterpenoids (4–7), and three known lignans (8–10). The structures of all isolated compounds were elucidated via the interpretation of spectroscopic methods, especially 2D NMR and mass analyses. In the cytotoxic assays, compounds 1–3 and 7–10 showed inhibition effect against HepG2, MDA-MB-231, and A549 cells with IC₅₀ values ranging from 0.004 to 19.9 μg/mL. Moreover, the anti-inflammatory assays revealed that (–)-matairesinol (8) had significant inhibitory activities on superoxide anion generation (IC₅₀ = 2.7 ± 0.3 μM) and elastase release (IC₅₀ = 6.6 ± 0.7 μM).

柏树是防风林，据报道具有多种细胞毒性作用。上的叶子的天然产物研究C.大果已经产生了10的次级代谢产物，包括三个新的二萜类化合物（1 - 3），四种已知二萜类化合物（4 - 7），和三种已知的木酚素（8 - 10）。通过光谱方法的解释，特别是2D NMR和质量分析，阐明了所有分离化合物的结构。在细胞毒性测定中，化合物1 - 3和7 - 10对HepG2，MDA-MB-231和A549细胞具有抑制作用，IC ₅₀值为0.004至19.9μg/ mL。此外，抗炎试验显示，（–）-麦地甾醇（8）对超氧阴离子的产生（IC ₅₀ = 2.7±0.3μM）和弹性蛋白酶的释放（IC ₅₀ = 6.6± 0.7μM ）具有显着的抑制活性。