Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigated the BSI in mCRPC and its relationship with prognosis. The PubMed, Cochrane, and Embase databases were searched systematically for relevant articles published before September 1, 2019. Hazard ratios (HRs) were used to investigate the prognostic value. This study finally identified 9 eligible studies. The results suggested that high baseline BSI predicted poor OS (HR = 1.331, 95% CI: 1.081–1.640) and that elevated ΔBSI also predicted poor OS (HR = 1.220, 95% CI: 1.015–1.467). The subgroup analysis stratified by ethnicity showed that the baseline BSI and ΔBSI predicted poor OS in the Asian population but not in the Caucasian population. We also performed a subgroup analysis based on the different cut-off values of baseline BSI. The subgroup of ≤1 showed a significant association with OS in mCRPC patients. Our study demonstrated that high baseline BSI and elevated ΔBSI predicted poor OS in patients with mCRPC. Hence, the BSI can serve as a prognostic indicator for mCRPC patients and may therefore guide clinical treatment in the future.

中文翻译：

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骨扫描指数对转移性去势抵抗性前列腺癌患者的预后价值：系统评价和荟萃分析

许多研究报告了骨扫描指数（BSI）对转移性去势抵抗性前列腺癌（mCRPC）的预后意义；但是，这些报告是有争议的。本研究调查了mCRPC中的BSI及其与预后的关系。系统搜索了PubMed，Cochrane和Embase数据库，以查找2019年9月1日之前发布的相关文章。使用危险比（HRs）调查预后价值。这项研究最终确定了9项合格研究。结果表明，高基线BSI预测OS较差（HR = 1.331，95％CI：1.081–1.640），而较高的ΔBSI也预测OS较差（HR = 1.220，95％CI：1.015-1.467）。按种族分层的亚组分析显示，基线BSI和ΔBSI预测亚洲人群的OS较差，而白种人人群则不然。我们还根据基线BSI的不同临界值进行了亚组分析。≤1的亚组与mCRPC患者的OS显着相关。我们的研究表明，高基线BSI和升高的ΔBSI预测mCRPC患者的OS较差。因此，BSI可以作为mCRPC患者的预后指标，因此可以在将来指导临床治疗。