Diabetes is one of the most challenging global health problems, affecting more than 400 million people (1). Although 10% of current global health care spending is devoted to diabetes (1), patients with diabetes remain at high risk of morbidity and mortality (2) mainly due to cardiovascular disease (3). This extremely heavy burden is likely to increase in the coming decades, especially considering the epidemic nature of the most common form, type 2 diabetes (4). It is, therefore, mandatory to address vigorously the negative impact of type 2 diabetes on vascular health and life expectancy. To this end, the availability of well-performing risk prediction models capable of identifying high-risk patients to be targeted with the most aggressive and most burdensome prevention strategies would play a pivotal role.

中文翻译：

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朝着精确医学的方向发展需要高度可辨别，经过验证，廉价且易于使用的预测模型

糖尿病是全球最具挑战性的健康问题之一，影响了超过4亿人（1）。尽管当前全球医疗保健支出的10％用于糖尿病（1），但糖尿病患者仍然主要由于心血管疾病（3）而具有较高的发病率和死亡率风险（2）。在未来的几十年中，这种沉重的负担可能会增加，尤其是考虑到最常见的2型糖尿病的流行性（4）。因此，必须大力解决2型糖尿病对血管健康和预期寿命的负面影响。为此，性能良好的风险预测模型的可用性将发挥关键作用，该模型能够确定将以最积极，最繁重的预防策略作为目标的高风险患者。