Reconfigurable Self-Assembly and Kinetic Control of Multiprogrammed DNA-Coated Particles.,ACS Nano

当前位置： X-MOL 学术 › ACS Nano › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Reconfigurable Self-Assembly and Kinetic Control of Multiprogrammed DNA-Coated Particles.
ACS Nano ( IF 15.8 ) Pub Date : 2020-03-20 , DOI: 10.1021/acsnano.0c00164
Joon Suk Oh ₁ , Gi-Ra Yi ₂ , David J Pine _{1,

3}

Affiliation

DNA is a unique molecule for storing information, which is used to provide particular biological instructions. Its function is primarily determined by the sequence of its four nucleobases, which have highly specific base-pairing interactions. This unique feature can be applied to direct the self-assembly of colloids by grafting DNA onto them. Due to the sequence-specific interactions, colloids can be programmed with multiple instructions. Here, we show that particles having multiple DNA strands with different melting profiles can undergo multiple phase transitions and reassemble into different crystalline structures in response to temperature. We include free DNA strands in the medium to selectively switch on and off DNA hybridization depending on temperature. We also demonstrate that DNA hybridization kinetics can be used as a means to achieve targeted assembling structure of colloids. These transitions impart a reconfigurability to colloids in which systems can be transformed an arbitrary number of times using thermal and kinetic control.

中文翻译：

可重组装的自组装和动力学控制的多程序DNA包覆的粒子。

DNA是用于存储信息的独特分子，用于提供特定的生物学指令。它的功能主要由其四个核碱基的序列决定，这四个核碱基具有高度特异性的碱基配对相互作用。通过将DNA嫁接到胶体上，这种独特的功能可用于指导胶体的自组装。由于序列特定的相互作用，胶体可以用多个指令编程。在这里，我们表明具有多个具有不同熔解曲线的DNA链的粒子可以经历多个相变，并响应温度重新组装成不同的晶体结构。我们将游离DNA链包含在培养基中，以根据温度选择性地打开和关闭DNA杂交。我们还证明了DNA杂交动力学可以用作实现胶体靶向组装结构的一种手段。这些转变赋予胶体可重构性，其中可以使用热和动力学控制将系统变换任意次数。

更新日期：2020-03-20

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11