Sequential one-pot 2-iodoxybenzoic acid (IBX) oxidation of Morita–Baylis–Hillman (MBH) adducts followed by catalyst-free indolizine conjugate addition was developed. The wide scopes of MBH adducts and indolizines were investigated, and densely functionalized adducts were obtained in yields of up to 94%. The conjugate addition step occurred in less than a minute at room temperature with total regioselectivity toward indolizine C3 carbon. Less nucleophilic C1 carbon was also alkylated when C3-substituted indolizines were employed as the substrate.

中文翻译：

---

吲哚胺类化合物在原位生成的氧化森田-贝利斯-希尔曼加合物上无催化剂的共轭加成反应

开发了森田-贝利斯-希尔曼（MBH）加合物的顺序一锅法2-碘氧基苯甲酸（IBX）氧化，然后加入无催化剂的吲哚嗪共轭物。研究了广泛的MBH加合物和吲哚嗪类化合物，并获得了功能密集的加合物，收率高达94％。缀合物添加步骤在室温下不到一分钟的时间内发生，对吲哚嗪C3碳的总区域选择性高。当使用C3取代的吲哚嗪作为底物时，较少的亲核C1碳也被烷基化。