Sub- and Supramolecular X-Ray Characterization of Engineered Tissues from Equine Tendon, Bovine Dermis, and Fish Skin Type-I Collagen.,Macromolecular Bioscience

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Sub- and Supramolecular X-Ray Characterization of Engineered Tissues from Equine Tendon, Bovine Dermis, and Fish Skin Type-I Collagen.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-03-12 , DOI: 10.1002/mabi.202000017
Alberta Terzi ₁ , Nunzia Gallo ₂ , Simona Bettini ₂ , Teresa Sibillano ₁ , Davide Altamura ₁ , Marta Madaghiele ₂ , Liberato De Caro ₁ , Ludovico Valli ₃ , Luca Salvatore ₂ , Alessandro Sannino ₂ , Cinzia Giannini ₁

Affiliation

Collagen represents one of the most widely used biomaterial for scaffolds fabrication in tissue engineering as it represents the mechanical support of natural tissues. It also provides physical scaffolding for cells and it influences their attachment, growth, and tissue regeneration. Among all fibrillary collagens, type I is considered one of the gold standard for scaffolds fabrication, thanks to its high biocompatibility, biodegradability, and hemostatic properties. It can be extracted by chemical and enzymatic protocols from several collagen‐rich tissues, such as tendon and skin, of different animal species. Both the extraction processes and the manufacturing protocols for scaffolds fabrication provide structural and mechanical changes that can be tuned in order to deeply impact the properties of the final biomaterial. The aim of this review is to discuss the role of X‐rays to study structural changes of type I collagen from fresh collagen‐rich tissues (bovine, equine, fish) to the final scaffolds, with the aim to screen across available collagen sources and scaffolds fabrication protocols to be used in tissue regeneration.

中文翻译：

马肌腱，牛真皮和鱼皮I型胶原蛋白的工程组织的亚分子和超分子X射线表征。

胶原蛋白代表了组织工程中支架制造中使用最广泛的生物材料之一，因为它代表了天然组织的机械支撑。它还为细胞提供物理支架，并影响细胞的附着，生长和组织再生。在所有原纤维胶原中，由于其高的生物相容性，生物降解性和止血性能，I型被认为是制造支架的金标准之一。可以通过化学和酶促方法从不同动物物种的几种富含胶原蛋白的组织（例如肌腱和皮肤）中提取。脚手架制造的提取过程和制造规程都提供了可以调整的结构和机械变化，以深刻影响最终生物材料的性能。

更新日期：2020-03-12

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