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The effect of coenzyme Q10 supplementation on oxidative stress: A systematic review and meta-analysis of randomized controlled clinical trials.
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-03-19 , DOI: 10.1002/fsn3.1492 Zohreh Sadat Sangsefidi 1, 2 , Fatemeh Yaghoubi 3 , Salimeh Hajiahmadi 1, 2 , Mahdieh Hosseinzadeh 1, 2
Food Science & Nutrition ( IF 3.5 ) Pub Date : 2020-03-19 , DOI: 10.1002/fsn3.1492 Zohreh Sadat Sangsefidi 1, 2 , Fatemeh Yaghoubi 3 , Salimeh Hajiahmadi 1, 2 , Mahdieh Hosseinzadeh 1, 2
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Some evidence exists in supporting the beneficial effects of coenzyme Q10 (CoQ10) on oxidative stress. Since the findings of studies over the impact of CoQ10 supplementation on oxidative stress are contradictory, this study was conducted. The aim was to evaluate CoQ10 supplementation effect on total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) levels using data collected from randomized controlled trials (RCTs). Several databases including PubMed, Web of Science, Google Scholar, and Scopus were comprehensively searched up to 23 January 2019 to identify RCTs. A random‐effects model, standardized mean difference (SMD), and 95% confidence interval (CI) were applied for data analysis. According to the meta‐analysis results on 19 eligible studies, CoQ10 increased the levels of TAC (SMD = 1.29; 95% CI = 0.35–2.23; p = .007), GPX (SMD = 0.45; 95% CI = 0.17–0.74; p = .002), SOD (SMD = 0.63; 95% CI = 0.29–0.97; p < .0001), and CAT (SMD = 1.67; 95% CI = 0.29–3.10; p = .018) significantly. This supplementation also caused a significant reduction in MDA levels (SMD = −1.12; 95% CI = −1.58 to −0.65; p < .0001). However, the results of SOD and CAT should be stated carefully due to the publication bias. In conclusion, this research indicated that CoQ10 supplementation had beneficial effects on oxidative stress markers. However, further studies are needed to confirm these findings.
中文翻译：
辅酶 Q10 补充剂对氧化应激的影响：随机对照临床试验的系统回顾和荟萃分析。
一些证据支持辅酶 Q10 (CoQ10) 对氧化应激的有益作用。由于补充 CoQ10 对氧化应激影响的研究结果相互矛盾，因此进行了这项研究。目的是利用随机对照试验 (RCT) 收集的数据来评估补充 CoQ10 对总抗氧化能力 (TAC)、丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GPx)、超氧化物歧化酶 (SOD) 和过氧化氢酶 (CAT) 水平的影响。截至 2019 年 1 月 23 日，对包括 PubMed、Web of Science、Google Scholar 和 Scopus 在内的多个数据库进行了全面检索，以确定随机对照试验。应用随机效应模型、标准化均差（SMD）和95%置信区间（CI）进行数据分析。根据 19 项合格研究的荟萃分析结果，CoQ10 增加了 TAC（SMD = 1.29；95% CI = 0.35–2.23； p = .007）、GPX（SMD = 0.45；95% CI = 0.17–0.74）水平; p = .002)、SOD (SMD = 0.63; 95% CI = 0.29–0.97; p < .0001) 和 CAT (SMD = 1.67; 95% CI = 0.29–3.10; p = .018) 显着。这种补充剂还导致 MDA 水平显着降低（SMD = -1.12；95% CI = -1.58 至 -0.65； p < .0001）。然而，由于发表偏倚，SOD 和 CAT 的结果应谨慎表述。总之，这项研究表明补充 CoQ10 对氧化应激标志物有有益的影响。然而，需要进一步的研究来证实这些发现。
更新日期：2020-03-19
中文翻译：
辅酶 Q10 补充剂对氧化应激的影响：随机对照临床试验的系统回顾和荟萃分析。
一些证据支持辅酶 Q10 (CoQ10) 对氧化应激的有益作用。由于补充 CoQ10 对氧化应激影响的研究结果相互矛盾，因此进行了这项研究。目的是利用随机对照试验 (RCT) 收集的数据来评估补充 CoQ10 对总抗氧化能力 (TAC)、丙二醛 (MDA)、谷胱甘肽过氧化物酶 (GPx)、超氧化物歧化酶 (SOD) 和过氧化氢酶 (CAT) 水平的影响。截至 2019 年 1 月 23 日，对包括 PubMed、Web of Science、Google Scholar 和 Scopus 在内的多个数据库进行了全面检索，以确定随机对照试验。应用随机效应模型、标准化均差（SMD）和95%置信区间（CI）进行数据分析。根据 19 项合格研究的荟萃分析结果，CoQ10 增加了 TAC（SMD = 1.29；95% CI = 0.35–2.23； p = .007）、GPX（SMD = 0.45；95% CI = 0.17–0.74）水平; p = .002)、SOD (SMD = 0.63; 95% CI = 0.29–0.97; p < .0001) 和 CAT (SMD = 1.67; 95% CI = 0.29–3.10; p = .018) 显着。这种补充剂还导致 MDA 水平显着降低（SMD = -1.12；95% CI = -1.58 至 -0.65； p < .0001）。然而，由于发表偏倚，SOD 和 CAT 的结果应谨慎表述。总之，这项研究表明补充 CoQ10 对氧化应激标志物有有益的影响。然而，需要进一步的研究来证实这些发现。
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