Abstract

In this work, by appealing to a heterometallic cluster approach, a new highly porous metal-organic framework (MOF) formulated as {(Me₂NH₂)[Ni₃K₂(TZIA)₃(H₂O)₃]·(DMF)₄}_n (1) has been fabricated by a solvothermal reaction of a bifunctional organic ligand 5-(1 H-tetrazol-5-yl)isophthalic acid (H₃TZIA) with the Ni(II) and K(I) salts in water and DMF mixed solvents. The resulting activated 1a has been explored in detail for BET analysis to probe its porosity. The removal of water molecule at the aim of generating 1a makes K⁺ ion become a heterogeneous catalyst of size-selective with high efficiency for solvent-free cyanosilylation of acetaldehyde under mild conditions. Furthermore, the prevention effect of the compound on the arrhythmia occurrences after anesthesia during operation was evaluated. The arrhythmia incidence and abnormal blood pressure was calculated and measured for the detection of compound prevention ability. Besides, the Norepinephrine (NE) and Adrenaline (A) released by the cardiomyocytes were measured by the ELISA kit.

摘要

在这项工作中，通过呼吁采用异金属簇方法，一种新的高度多孔的金属有机骨架（MOF）公式化为{（Me ₂ NH ₂）[Ni ₃ K ₂（TZIA）₃（H ₂ O）₃ ]·（ DMF）₄ } _n（1）是通过双官能有机配体5-（1 H-四唑-5-基）间苯二甲酸（H ₃ TZIA）与Ni（II）和K（I）的溶剂热反应制备的。在水和DMF混合溶剂中的盐。已经对所得的活化的1a进行了详细的探索，以进行BET分析以探测其孔隙率。以产生1a为目的去除水分子使K ⁺离子成为温和条件下高效选择乙醛的无溶剂氰基硅烷化异构催化剂。此外，评价了该化合物对手术期间麻醉后心律失常发生的预防作用。计算并测量心律失常的发生率和血压异常，以检测化合物的预防能力。此外，通过ELISA试剂盒测定了由心肌细胞释放的去甲肾上腺素（NE）和肾上腺素（A）。