Abstract Targeted drug delivery has become an increasingly popular field of research over the past decade as the desire for more discriminatory methods of treatment has risen. Photoacoustic-mediated drug delivery utilizing core-shell magnetoelectric nanocomposites has the potential to provide localized administration of medicine or even induce apoptosis via irreversible cellular electroporation. To design these systems, the suitability of specific materials must be assessed and quantified. This work reports on the photoacoustic properties found in ferromagnetic CoFe2O4 nanoparticles and magnetoelectric CoFe2O4-BaTiO3 nanocomposites, as well as the impact of core size on the photoacoustic spectra measured. The photoacoustic response of the core-shell nanocomposites was found to be significantly attenuated when compared to the pure CoFe2O4 nanoparticles. This indicates the ferroelectric BaTiO3 shell is absorbing a percentage of the generated acoustic waves, demonstrating the capability to implement these nanocomposites in a photoacoustic-mediated drug delivery system.

中文翻译：

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CoFe2O4 和 CoFe2O4-BaTiO3 核壳磁电纳米粒子的光声行为

摘要 在过去十年中，随着对更具歧视性的治疗方法的需求增加，靶向药物递送已成为越来越受欢迎的研究领域。利用核-壳磁电纳米复合材料的光声介导的药物递送有可能提供局部给药，甚至通过不可逆的细胞电穿孔诱导细胞凋亡。为了设计这些系统，必须评估和量化特定材料的适用性。这项工作报告了在铁磁 CoFe2O4 纳米颗粒和磁电 CoFe2O4-BaTiO3 纳米复合材料中发现的光声特性，以及纤芯尺寸对测量的光声光谱的影响。与纯 CoFe2O4 纳米颗粒相比，核壳纳米复合材料的光声响应显着减弱。这表明铁电 BaTiO3 壳吸收了一定比例的产生的声波，证明了在光声介导的药物递送系统中实施这些纳米复合材料的能力。