Abstract A simple and rapid method employing ultra-high performance liquid chromatography tandem mass spectrometry has been developed for the direct determination of acrylic acid in tap water for the first time. The method worked on a ultra-high-performance liquid chromatography system and utilized the direct injection of 10 μL volumes. Aqueous samples were filtered with 0.22 μm membrane after diluting with the acetonitrile without any further pretreatment. The separation was accomplished by using a HILIC column with a gradient elution program. Acetonitrile and ammonium acetate solution (pH = 7) were applied in the method as the mobile phase. Acrylic acid- d3 was used as the internal standard in the quantification process. The method provided good recovery from 102.8% to 104.4%, good precision with intraday relative standard deviations in a range of 2.3% and 5.1%. The limit of quantification for the method was 45 μg/L. The possible structures of qualitative ion and quantitative ion of acrylic acid were proposed in this work with the help of the product ion spectra of acrylic acid and its corresponding isotopic standards. This study provided a reliable and quantitative method that could be used for daily monitoring of water quality. GRAPHICAL ABSTRACT

中文翻译：

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UPLC-MS/MS法测定自来水中的丙烯酸

摘要 首次建立了一种简便、快速的超高效液相色谱串联质谱法直接测定自来水中的丙烯酸。该方法适用于超高效液相色谱系统，并采用 10 μL 体积的直接进样。用水样样品用乙腈稀释后用 0.22 μm 滤膜过滤，无需任何进一步的预处理。分离是通过使用带有梯度洗脱程序的 HILIC 柱完成的。在该方法中使用乙腈和醋酸铵溶液 (pH = 7) 作为流动相。丙烯酸-d3 用作定量过程中的内标。该方法提供了从 102.8% 到 104.4% 的良好回收率，良好的精密度，日内相对标准偏差在 2.3% 和 5.1% 的范围内。该方法的定量限为 45 μg/L。借助丙烯酸的产物离子谱图及其相应的同位素标准，本文提出了丙烯酸定性离子和定量离子的可能结构。该研究提供了一种可靠的定量方法，可用于水质的日常监测。图形概要 该研究提供了一种可靠的定量方法，可用于水质的日常监测。图形概要 该研究提供了一种可靠的定量方法，可用于水质的日常监测。图形概要