ABSTRACT Two seed storage proteins, glycinin and β-conglycinin, account for most of the proteins in soymeal, while a valuable source of protein, soybean, has also been reported to be allergenic in some animals. Glycinin and conglycinin have been reported as allergens in multiple species, including humans. Allergic responses to soy proteins are due to hypersensitivity immunological reactions upon consumption of protein. We have isolated antibodies from chicken eggs to demonstrate that chickens mount an immunogenic response to soy glycinin. All three classes of chicken immunoglobulins bound glycinin protein. We identify immunogenic regions unique to each glycinin protein that bind unique repertoires of IgA, IgM and IgY. This knowledge can be used to identify variants of immunogenic glycinin epitopes to determine the role these immunogenic sites play in the allergic response of chickens to soy protein.

中文翻译：

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鸡两种大豆大豆球蛋白免疫原性表位的鉴定

摘要 两种种子储存蛋白，大豆球蛋白和 β-伴大豆球蛋白，占豆粕中的大部分蛋白质，而据报道，大豆是一种宝贵的蛋白质来源，对某些动物具有过敏性。据报道，大豆球蛋白和伴大豆球蛋白是多种物种（包括人类）的过敏原。对大豆蛋白的过敏反应是由于摄入蛋白质后的超敏免疫反应。我们从鸡蛋中分离出抗体，以证明鸡对大豆大豆球蛋白产生免疫原性反应。所有三类鸡免疫球蛋白都结合大豆球蛋白。我们确定了每个大豆球蛋白独特的免疫原性区域，这些区域结合了独特的 IgA、IgM 和 IgY 库。