Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration.,Biomaterials Science

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Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-06 , DOI: 10.1039/d0bm00104j
Weinan Cheng ₁ , Zhaozhao Ding ₂ , Xin Zheng ₃ , Qiang Lu ₄ , Xiangdong Kong ₅ , Xiaozhong Zhou ₆ , Guozhong Lu ₂ , David L Kaplan ₇

Affiliation

Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215000, People's Republic of China. and Department of Burns and Plastic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi 214041, People's Republic of China. and Department of Orthopedics, The First Affiliated Hospital of Xiamen University, Xiamen 361000, People's Republic of China.
Department of Burns and Plastic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi 214041, People's Republic of China.
Department of Orthopedics, Taizhou Municipal Hospital, Taizhou 318000, People's Republic of China.
Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215000, People's Republic of China. and Department of Burns and Plastic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi 214041, People's Republic of China.
Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, People's Republic of China.
Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215000, People's Republic of China.
Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, USA.

Bone regeneration is a complex process in which angiogenesis and osteogenesis are crucial. Introducing multiple angiogenic and osteogenic cues simultaneously into a single system and tuning these cues to optimize the niche remains a challenge for bone tissue engineering. Herein, based on our injectable biomimetic hydrogels composed of silk nanofibers (SNF) and hydroxyapatite nanoparticles (HA), deferoxamine (DFO) and bone morphogenetic protein-2 (BMP-2) were loaded on SNF and HA to introduce more angiogenic and osteogenic cues. The angiogenesis and osteogenesis capacity of injectable hydrogels could be regulated by tuning the delivery of DFO and BMP-2 independently, resulting in vascularization and bone regeneration in cranial defects. The angiogenesis and osteogenesis outcomes accelerated the regeneration of vascularized bones toward similar composition and structure to natural bones. Therefore, the multiple biophysical and chemical cues provided by the nanofibrous structures, organic-inorganic compositions, and chemical and biochemical angiogenic and osteogenic inducing cues suggest the potential for clinical applicability of these hydrogels in bone tissue engineering.

中文翻译：

具有多种生物物理和生化线索的可注射水凝胶系统，可促进骨再生。

骨再生是一个复杂的过程，其中血管生成和骨生成至关重要。将多种血管生成和成骨线索同时引入单个系统并调整这些线索以优化利基仍然是骨组织工程的挑战。在此，基于我们由丝纳米纤维（SNF）和羟基磷灰石纳米颗粒（HA）组成的可注射仿生水凝胶，将去铁胺（DFO）和骨形态发生蛋白2（BMP-2）负载在SNF和HA上，以引入更多的血管生成和成骨线索。可通过独立调节 DFO 和 BMP-2 的递送来调节可注射水凝胶的血管生成和成骨能力，从而导致颅骨缺损中的血管化和骨再生。血管生成和成骨结果加速了血管化骨的再生，使其成分和结构与天然骨相似。因此，纳米纤维结构、有机-无机组合物以及化学和生化血管生成和成骨诱导线索提供的多种生物物理和化学线索表明这些水凝胶在骨组织工程中的临床应用潜力。

更新日期：2020-03-19

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