Au nanoparticles deposited on ultrathin two-dimensional covalent organic framework nanosheets for in vitro and intracellular sensing,Nanoscale

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Au nanoparticles deposited on ultrathin two-dimensional covalent organic framework nanosheets for in vitro and intracellular sensing
Nanoscale ( IF 5.8 ) Pub Date : 2020/03/20 , DOI: 10.1039/c9nr08220d
Yuanyuan Tian _{1,

2,

3,

4,

5} , Qipeng Lu _{6,

7,

8,

9} , Xixi Guo _{1,

2,

3,

4,

5} , Siyu Wang _{1,

2,

3,

4,

5} , Yu Gao _{1,

2,

3,

4,

5} , Lianhui Wang _{1,

2,

3,

4,

5}

Affiliation

A novel composite nanomaterial is prepared by growing small Au nanoparticles on two-dimensional covalent organic framework nanosheets (Au NPs/COF NSs). The synthesized hybrid nanosheets are used as a new platform for multiplexed detection of hepatitis A virus DNA (HAV) and hepatitis B virus DNA (HBV). Additionally, this sensing platform based on Au NPs/COF NSs can be used as a candidate for monitoring the distribution of potassium ions (K⁺) and the intracellular K⁺ level in living cells. Accordingly, the sensing systems based on hybrid Au NPs/COF NSs have shown great potential for the investigation of biomolecules and related biological applications.

中文翻译：

沉积在超薄二维共价有机骨架纳米片上的金纳米颗粒，用于体外和细胞内传感

通过在二维共价有机骨架纳米片（Au NPs / COF NSs）上生长小的Au纳米粒子，制备了一种新型的复合纳米材料。合成的杂化纳米片被用作多重检测甲型肝炎病毒DNA（HAV）和乙型肝炎病毒DNA（HBV）的新平台。另外，该基于Au NPs / COF NSs的传感平台可以用作监测活细胞中钾离子（K ⁺）分布和细胞内K ⁺水平的候选对象。因此，基于混合金纳米颗粒/ COF NSs的传感系统已显示出研究生物分子和相关生物应用的巨大潜力。

更新日期：2020-04-09

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