Abstract

Currently, wound infection is an important health problem for the public. Wound infection can not only hinder healing but it can also lead to serious complications. Injectable wound dressings with biocompatible and antibacterial properties can promote wound healing during skin infections and reduce antibiotic use. Here, we used glycidyl methacrylate (GMA) to modify ε-polylysine (ε-PL) and γ-poly(glutamic acid) (γ-PGA) to produce ε-polylysine-glycidyl methacrylate (ε-PL-GMA) and γ-poly(glutamic acid)-glycidyl methacrylate (γ-PGA-GMA). Subsequently, ε-PL-GMA- and γ-PGA-GMA-based hydrogels were developed through photopolymerization using visible light. The hydrogels were injectable, could rapidly gelatinize, were biocompatible, and showed a wide spectrum of antibacterial activity. The hydrogels also promoted wound healing. The results show that these hydrogels inhibit bacterial infection and shorten the wound healing time of skin defects in Staphylococcus aureus models. This demonstrates that the hydrogels hold potential for clinical antimicrobial and wound healing therapy.

中文翻译：

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具有抗微生物和生物相容性的可注射光聚合水凝胶，可用于感染的皮肤再生

摘要

当前，伤口感染是公众的重要健康问题。伤口感染不仅会阻碍愈合，还会导致严重的并发症。具有生物相容性和抗菌特性的可注射伤口敷料可以促进皮肤感染期间的伤口愈合，并减少抗生素的使用。在这里，我们使用甲基丙烯酸缩水甘油酯（GMA）对ε-聚赖氨酸（ε-PL）和γ-聚谷氨酸（γ-PGA）进行改性，以生产ε-聚赖氨酸-甲基丙烯酸缩水甘油酯（ε-PL-GMA）和γ-聚（谷氨酸）-甲基丙烯酸缩水甘油酯（γ-PGA-GMA）。随后，使用可见光通过光聚合反应开发了基于ε-PL-GMA和γ-PGA-GMA的水凝胶。该水凝胶可注射，可迅速糊化，具有生物相容性，并显示出广泛的抗菌活性。水凝胶还促进伤口愈合。金黄色葡萄球菌模型。这表明水凝胶具有用于临床抗菌和伤口愈合疗法的潜力。