To understand and improve the translocation dynamics of nanopore based sensors, we studied theoretically the translocation of DNA molecules and compared them with experimental results. In our experimental studies, we used conically shaped track-etched polymer (i.e., PET) membrane and built our model based on its physical properties. Simulations were conducted by varying the surface charges of the nanopore and the particle, particle (i.e., DNA) position and applied potential to examine the translocational behavior of DNA and its effect on current-pulse shape. Our results showed that variations in surface and DNA charge density cause conductive distortions indicating the interaction between the surface and the DNA. It also confirmed that the DNA charge density does not remain in its native form in the solution as well as the pore charge during the translocation.

中文翻译：

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研究带电成分对轨迹蚀刻纳米孔中 DNA 分子易位的影响

为了理解和改进基于纳米孔的传感器的易位动力学，我们从理论上研究了 DNA 分子的易位并将其与实验结果进行了比较。在我们的实验研究中，我们使用了锥形轨道蚀刻聚合物（即 PET）膜，并根据其物理特性建立了我们的模型。通过改变纳米孔和粒子的表面电荷、粒子（即 DNA）位置和施加的电位进行模拟，以检查 DNA 的易位行为及其对电流脉冲形状的影响。我们的结果表明，表面和 DNA 电荷密度的变化会导致导电扭曲，表明表面和 DNA 之间的相互作用。