Creatinine (CR) produced through the muscle metabolism acts as biomarker to monitor the kidney functioning of the human body. In this study, a successful effort has been made to develop a fast and easy detection method for the monitoring of CR concentration in an aqueous solution as well as in the artificial urine sample. The sensor has been developed over a lossy mode resonance (LMR) based optical fiber platform using MoS₂@SnO₂ nanocomposite as LMR supporting material and MoS₂@SnO₂ nanocomposite along with CR imprinted polymer film as artificial antibodies. The sensor’s performance has been studied for the CR concentration range from 0 to $2000~\mu \text{g}$ /mL which lies within the physiological range found in human blood and urine. The maximum sensitivity and detection limit of the sensor have been found to be 0.41 nm/( $\mu \text{g}$ /mL) and $1.86~\mu \text{g}$ /mL, respectively. The sensor has several advantages such as high selectivity, long-term stability, repeatability and fast response. The recovery of the sensor probes close to 100% with the artificial urine sample shows its potential use in the biomedical application.

中文翻译：

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使用分子印迹在 MoS2/SnO2 纳米复合材料上制造的基于损耗模式共振的光纤肌酐传感器

通过肌肉代谢产生的肌酐 (CR) 作为生物标志物来监测人体的肾脏功能。在这项研究中，成功​​地开发了一种快速简便的检测方法，用于监测水溶液和人工尿样中的 CR 浓度。该传感器是在基于损耗模式共振 (LMR) 的光纤平台上开发的，使用 MoS ₂ @SnO ₂纳米复合材料作为 LMR 支撑材料，MoS ₂ @SnO ₂纳米复合材料以及 CR 印迹聚合物薄膜作为人工抗体。已经研究了传感器在 CR 浓度范围从 0 到 $2000~\mu \text{g}$ /mL 位于人体血液和尿液中的生理范围内。已发现传感器的最大灵敏度和检测限为 0.41 nm/( $\mu \text{g}$ /mL) 和 $1.86~\mu \text{g}$ /mL，分别。该传感器具有选择性高、长期稳定性好、重复性好、响应快等优点。传感器探针与人造尿样的回收率接近 100%，表明其在生物医学应用中的潜在用途。