In vivo and in vitro studies of differential continuous wave photoacoustic spectroscopy (DCW-PAS) for non-invasive blood glucose monitoring were performed. The DCW-PAS technique utilizes amplitude modulation of dual wavelengths of light to determine changes in glucose concentration. The study compared DCW-PAS measurements with results from invasive blood glucose sensor measurements during oral glucose tolerance tests (OGTTs) of healthy people. The trends in blood glucose levels (BGLs) obtained from invasive sensors and from the photoacoustic signal have good agreement, with the standard error and correlation coefficient against BGLs of 48 mg/dL or less and 0.80, respectively. Our proposed photoacoustic spectroscopy (PAS) method shows high potential for use in a non-invasive BGL sensor.

中文翻译：

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用于无创血糖监测的差分连续波光声光谱

进行了用于无创血糖监测的差分连续波光声光谱 (DCW-PAS) 的体内和体外研究。DCW-PAS 技术利用双波长光的幅度调制来确定葡萄糖浓度的变化。该研究将 DCW-PAS 测量结果与健康人口服葡萄糖耐量试验 (OGTT) 期间侵入性血糖传感器测量结果进行了比较。从侵入式传感器和光声信号获得的血糖水平 (BGL) 趋势具有良好的一致性，标准误差和与 BGL 的相关系数分别为 48 mg/dL 或更低和 0.80。我们提出的光声光谱 (PAS) 方法显示出在非侵入性 BGL 传感器中使用的巨大潜力。