Enrichment of biomass containing high lipid content is the key limiting step for the utilization of cyanobacterial feedstock in biodiesel production. This study investigated the influence of antibiotics on the biodiesel productivity of a model biodiesel-producing cyanobacterium (Synechocystis sp. PCC 6803) through a 18-day exposure test and observed that 100 ng/L of ciprofloxacin, amoxicillin, and spiramycin significantly (p < 0.05) increased biomass, chlorophyll a content, and F_v/F_m value and rETR_max value in Synechocystis sp. PCC 6803. Due to the stimulation of photosynthesis, the 18-day dry weights of the cyanobacterial cells increased from 0.354 ± 0.039 to 0.508 ± 0.048, 0.58 ± 0.028, and 0.66 ± 0.028 g/L under exposure to ciprofloxacin, amoxicillin, and spiramycin, respectively. As a stress response to antibiotics, the lipid content in Synechocystis sp. PCC 6803 increased from 14.71 to 20.92%, 20.59%, and 15.36% under exposure to ciprofloxacin, amoxicillin, and spiramycin, respectively. Due to the increase of biomass and lipid content, the lipid productivity of Synechocystis sp. PCC 6803 increased from 2.89 to 5.90, 6.63, and 5.63 mg/L/d under exposure to ciprofloxacin, amoxicillin, and spiramycin, respectively. Exposure to each target antibiotic increased the proportion of monounsaturated fatty acids in the lipid, while exposure to spiramycin reduced the proportion of saturated fatty acid. Antibiotics regulated the lipid composition of Synechocystis sp. PCC 6803 towards an increase of combustion property. This study proved that antibiotic exposure increased the lipid productivity of cyanobacteria through hormesis, which provided new insights for promoting the production of cyanobacteria-based biodiesel.

中文翻译：

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蓝藻的生长速度，光合活性和生物柴油生产力的变化。PCC 6803在抗生素暴露下

富含高脂质的生物质的富集是在生物柴油生产中利用蓝细菌原料的关键限制步骤。这项研究通过18天的暴露测试，研究了抗生素对模型生物柴油生产蓝细菌（Synechocystis sp。PCC 6803）的生物柴油生产率的影响，并观察到100 ng / L的环丙沙星，阿莫西林和螺旋霉素显着（p  < 0.05）增加了集胞藻的生物量，叶绿素a含量以及F _v / F _m值和rETR_最大值sp。PCC6803。由于光合作用的刺激，在暴露于环丙沙星，阿莫西林和螺旋霉素的作用下，蓝细菌细胞的18天干重从​​0.354±0.039 g / L增加到0.508±0.048、0.58±0.028和0.66±0.028 g / L。 ， 分别。作为对抗生素的应激反应，Synechocystis sp。中的脂质含量。暴露于环丙沙星，阿莫西林和螺旋霉素的PCC 6803分别从14.71％增加到20.92％，20.59％和15.36％。由于生物量和脂质含量的增加，集胞藻的脂质生产力sp。在暴露于环丙沙星，阿莫西林和螺旋霉素的作用下，PCC 6803分别从2.89增加到5.90、6.63和5.63 mg / L / d。暴露于每种靶抗生素会增加脂质中单不饱和脂肪酸的比例，而暴露于螺旋霉素会降低饱和脂肪酸的比例。抗生素调节了集胞藻的脂质组成。PCC 6803致力于提高燃烧性能。这项研究证明了抗生素的接触通过兴奋作用提高了蓝细菌的脂质生产率，这为促进基于蓝细菌的生物柴油的生产提供了新的见解。