Scientists have recommended to investigate graphene and graphene base compounds for their potential uses in a variety of fields, such as biomedicine and drug release. A PEGylated and functionalized magnetic graphene oxide (MG–NH₂–PEG) complex was used herein as a nanocarrier of Doxorubicin, a cancer chemotherapy drug. First, graphene oxide was synthesized by modified Hummer’s method and then functionalized with amine groups (G–NH₂). Afterwards, solvothermal of Fe₃O₄ magnetic nanoparticles on G–NH₂ to prepare magnetic graphene oxide (MGO) modified by MG–NH₂ via covalent bindings for the synthesis of MG–NH₂–PEG. Doxorubicin (DOX) was loaded onto MG–NH₂–PEG at pH 7 by the use of π–π interactions, yielding a highly significant value of DOX's loading efficiency along with its loading content. In vitro cytotoxicity tests on MCF-7 cells line were carried out for MG–NH₂–PEG: DOX according to the drug loading and release characteristics. The results of standard MTT assay for the toxicity determination of both synthetic nanocomposites and the drug revealed over 85% of surviving cells after 48 h, with a cellular uptake of > 80%, suggesting a satisfactory outcome on the non-toxicity of the nanocomposite. It can, therefore, be concluded that MG–NH₂–PEG showed to be an effective drug carrier in cancer chemotherapy drug delivery through loading the above drugs of low medicinal properties with individual dependency on pH levels. Furthermore, MG–NH₂–PEG represent strong optical absorbance from the visible to the near-infrared (NIR) region, and can be utilized for localized photothermal ablation of cancer cells guided by the magnetic field.

中文翻译：

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石墨烯/氧化铁纳米复合材料的聚乙二醇化：评估阿霉素的释放，磁性靶向药物递送和光热疗法

科学家建议研究石墨烯和石墨烯基化合物在各种领域的潜在用途，例如生物医学和药物释放。聚乙二醇化和功能化的磁性氧化石墨烯（MG-NH ₂ -PEG）络合物在本文中用作癌症化疗药物阿霉素的纳米载体。首先，通过改良的Hummer方法合成氧化石墨烯，然后用胺基（G–NH ₂）进行官能化。然后，在G–NH ₂上对Fe ₃ O ₄磁性纳米粒子进行溶剂热，以制备MG–NH ₂通过共价键合而被MG–NH ₂改性的磁性石墨烯（MGO），以合成MG–NH ₂ –PEG。阿霉素（DOX）被加载到MG–NH通过使用π-π相互作用，在pH为7的₂ –PEG中，产生了DOX的负载效率及其负载量的极高值。根据载药和释放特征，对MG-NH ₂ -PEG：DOX进行了MCF-7细胞系的体外细胞毒性测试。用于合成纳米复合材料和药物的毒性测定的标准MTT分析结果表明，48小时后有超过85％的存活细胞，细胞摄取> 80％，表明该纳米复合材料的无毒性令人满意。因此，可以得出结论：MG–NH ₂–PEG通过装载上述药物的低药物性和对pH值的依赖性而被证明是有效的癌症化疗药物载体。此外，MG-NH ₂ -PEG从可见光到近红外（NIR）区域都有很强的吸光度，可用于磁场引导下的癌细胞的局部光热消融。