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PEGylation of graphene/iron oxide nanocomposite: assessment of release of doxorubicin, magnetically targeted drug delivery and photothermal therapy
Applied Nanoscience Pub Date : 2020-01-30 , DOI: 10.1007/s13204-020-01255-8
Marzieh Ramezani Farani , Parissa Khadiv-Parsi , Gholam Hossein Riazi , Mehdi Shafiee Ardestani , Hamidreza Saligheh Rad

Scientists have recommended to investigate graphene and graphene base compounds for their potential uses in a variety of fields, such as biomedicine and drug release. A PEGylated and functionalized magnetic graphene oxide (MG–NH2–PEG) complex was used herein as a nanocarrier of Doxorubicin, a cancer chemotherapy drug. First, graphene oxide was synthesized by modified Hummer’s method and then functionalized with amine groups (G–NH2). Afterwards, solvothermal of Fe3O4 magnetic nanoparticles on G–NH2 to prepare magnetic graphene oxide (MGO) modified by MG–NH2 via covalent bindings for the synthesis of MG–NH2–PEG. Doxorubicin (DOX) was loaded onto MG–NH2–PEG at pH 7 by the use of π–π interactions, yielding a highly significant value of DOX's loading efficiency along with its loading content. In vitro cytotoxicity tests on MCF-7 cells line were carried out for MG–NH2–PEG: DOX according to the drug loading and release characteristics. The results of standard MTT assay for the toxicity determination of both synthetic nanocomposites and the drug revealed over 85% of surviving cells after 48 h, with a cellular uptake of > 80%, suggesting a satisfactory outcome on the non-toxicity of the nanocomposite. It can, therefore, be concluded that MG–NH2–PEG showed to be an effective drug carrier in cancer chemotherapy drug delivery through loading the above drugs of low medicinal properties with individual dependency on pH levels. Furthermore, MG–NH2–PEG represent strong optical absorbance from the visible to the near-infrared (NIR) region, and can be utilized for localized photothermal ablation of cancer cells guided by the magnetic field.

中文翻译:

石墨烯/氧化铁纳米复合材料的聚乙二醇化:评估阿霉素的释放,磁性靶向药物递送和光热疗法

科学家建议研究石墨烯和石墨烯基化合物在各种领域的潜在用途,例如生物医学和药物释放。聚乙二醇化和功能化的磁性氧化石墨烯(MG-NH 2 -PEG)络合物在本文中用作癌症化疗药物阿霉素的纳米载体。首先,通过改良的Hummer方法合成氧化石墨烯,然后用胺基(G–NH 2)进行官能化。然后,在G–NH 2上对Fe 3 O 4磁性纳米粒子进行溶剂热,以制备MG–NH 2通过共价键合而被MG–NH 2改性的磁性石墨烯(MGO),以合成MG–NH 2 –PEG。阿霉素(DOX)被加载到MG–NH通过使用π-π相互作用,在pH为7的2 –PEG中,产生了DOX的负载效率及其负载量的极高值。根据载药和释放特征,对MG-NH 2 -PEG:DOX进行了MCF-7细胞系的体外细胞毒性测试。用于合成纳米复合材料和药物的毒性测定的标准MTT分析结果表明,48小时后有超过85%的存活细胞,细胞摄取> 80%,表明该纳米复合材料的无毒性令人满意。因此,可以得出结论:MG–NH 2–PEG通过装载上述药物的低药物性和对pH值的依赖性而被证明是有效的癌症化疗药物载体。此外,MG-NH 2 -PEG从可见光到近红外(NIR)区域都有很强的吸光度,可用于磁场引导下的癌细胞的局部光热消融。
更新日期:2020-01-30
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