Abstract

The in vitro model of serum deprivation shows that the survival of SH-SY5Y neuronal cells is ensured by the intrinsic trophic activity of BDNF loop 4 mimetic GSB-106 (10^–7 М), which is comparable to that of endogenous neurotrophin (10^–9 М). The analysis of the cell cycle and S-phase showed that GSB-106, similarly to BDNF, induces the cell-cycle arrest in the G₁ phase, diminishes the number of cells in the S-phase, reduces the number of apoptotic cells, and does not stimulate proliferation.

中文翻译：

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低分子量化合物GSB-106模拟血清剥夺后BDNF的细胞作用。

抽象

的血清剥夺示出了体外模型，SH-SY5Y神经元细胞的存活通过BDNF环4模拟物GSB-106（10的固有营养活性确保^-7 М），这与内源性神经营养因子（10 ^{- 9} М）。细胞周期和S期的分析表明，与BDNF相似，GSB-106诱导G ₁期细胞周期停滞，减少了S期细胞的数量，减少了凋亡细胞的数量，并且不会刺激扩散。