Abstract

In the present study we showed that the recombinant analogue of the SLURP-1 protein effectively inhibits the growth of a 3D model of tumors—multicellular spheroids reconstructed from human epidermoid carcinoma A431 cells and human lung adenocarcinoma A549 cells. The combined application of rSLURP-1 with gefitinib (inhibitor of epidermal growth factor receptor (EGFR)) leads to the synergistic antiproliferative effect on spheroids from A431 cells. The results obtained suggest the possibility for design of first-in-class anticancer drugs based on recombinant SLURP-1.

中文翻译：

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人蛋白SLURP-1的重组类似物抑制从癌细胞中重建的多细胞球体的生长。

摘要

在本研究中，我们表明SLURP-1蛋白的重组类似物有效抑制了肿瘤的3D模型的生长-从人表皮样癌A431细胞和人肺腺癌A549细胞重建的多细胞球体。rSLURP-1与吉非替尼（表皮生长因子受体（EGFR）抑制剂）的联合应用可导致对A431细胞球体的协同抗增殖作用。获得的结果表明，基于重组SLURP-1设计一流抗癌药物的可能性。