Abstract

Purpose

To investigate the association between serum serotonin (5-HT) levels and overactive bladder (OAB) in a community-dwelling population.

Methods

This cross-sectional study analyzed 1024 subjects who participated in the Iwaki Health Promotion Project in 2015 in Hirosaki, Japan. OAB was assessed using the Overactive Bladder Symptom Score (OABSS). OAB was defined as an occurrence of urinary urgency at least once a week and an OABSS of ≥ 3. We assessed serum 5-HT levels, laboratory data, and comorbidities of each participants. Participants’ mental health status was evaluated using the Center for Epidemiologic Studies Depression (CES-D) scale. The association of serum 5-HT levels and OAB was analyzed by multivariable logistic regression analysis.

Results

This study included 394 men and 630 women. Of those, 118 (44 male and 74 female) were OAB sufferers. There were significant group differences in age, history of cardiovascular disease, chronic kidney disease, hypertension, diabetes mellitus, and CES-D score. Participants’ serum 5-HT levels in the OAB group were significantly lower than those in the non-OAB group (100 vs. 127 ng/mL, P < 0.001). Multivariable analysis showed that age (odds ratio [OR]; 1.06, 95% confidence interval [CI]; 1.04–1.08, P < 0.001) and log serum 5-HT level (OR; 0.25, 95% CI; 0.10–0.68, P = 0.006) were independently associated with OAB.

Conclusions

Lower serum 5-HT levels could independently be associated with the presence of OAB. Further study is necessary to elucidate a possible causal relationship between serum 5-HT levels and OAB.

中文翻译：

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血清 5-羟色胺水平与膀胱过度活动症之间的关联：日本一项基于社区的横断面研究的结果

摘要

目的

调查社区居住人群中血清血清素 (5-HT) 水平与膀胱过度活动症 (OAB) 之间的关联。

方法

这项横断面研究分析了 2015 年在日本弘前参加 Iwaki 健康促进项目的 1024 名受试者。OAB 使用膀胱过度活跃症状评分 (OABSS) 进行评估。OAB 定义为每周至少发生一次尿急且 OABSS ≥ 3。我们评估了每位参与者的血清 5-HT 水平、实验室数据和合并症。使用流行病学研究中心抑郁 (CES-D) 量表评估参与者的心理健康状况。血清5-HT水平与OAB的相关性通过多变量logistic回归分析进行分析。

结果

这项研究包括 394 名男性和 630 名女性。其中，118 人（44 名男性和 74 名女性）是 OAB 患者。年龄、心血管疾病史、慢性肾病、高血压、糖尿病和 CES-D 评分存在显着的组别差异。OAB 组参与者的血清 5-HT 水平显着低于非 OAB 组（100 vs. 127 ng/mL，P  < 0.001）。多变量分析显示年龄（优势比 [OR]；1.06，95% 置信区间 [CI]；1.04–1.08，P  < 0.001）和对数血清 5-HT 水平（OR；0.25，95% CI；0.10–0.68，P  = 0.006) 与 OAB 独立相关。

结论

较低的血清 5-HT 水平可能与 OAB 的存在独立相关。需要进一步研究以阐明血清 5-HT 水平与 OAB 之间可能的因果关系。